HitPredict

Interactor 1: SPRE1 (Q7Z699)
Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
Gene: SPRED1

Interactor 2: HPCL4 (Q9UM19)
Hippocalcin-like protein 4 (HLP4)
Gene: HPCAL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.50	0.603

Property	Details
Experiments	32296183, unassigned1304, 32814053
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 444 Hs			1 191
+	Hs
		789646 SPRE1_HUMAN (1-444): 3.83e-177: 504: 100.00		HPCL1_HUMAN (1-189): 2.15e-56: 178: 67.73
+	Hs
		962899 SPRE1_HUMAN (1-444): 3.83e-177: 504: 100.00		NCALD_HUMAN (1-189): 7.85e-55: 173: 65.61
+	Hs
		979418 SPRE1_HUMAN (1-444): 3.83e-177: 504: 100.00		VISL1_HUMAN (1-191): 1.09e-51: 165: 89.53
+	Hs
		1279765 SPRE1_HUMAN (1-444): 3.83e-177: 504: 100.00		KCIP2_HUMAN (9-187): 6.3e-46: 153: 43.58
+	Hs
		1279586 SPRE2_HUMAN (1-444): 1.37e-148: 430: 50.44		KCIP1_HUMAN (9-187): 1.61e-53: 171: 43.02
+	Hs
		979417 SPRE2_HUMAN (1-444): 1.37e-148: 430: 50.44		VISL1_HUMAN (1-191): 1.09e-51: 165: 89.53
+	Hs
		968641 SPRE2_HUMAN (1-444): 1.37e-148: 430: 50.44		NCS1_HUMAN (1-187): 3.23e-47: 154: 56.15
+	Hs
		221412 SPY3_HUMAN (201-435): 5.33e-43: 154: 16.79		VISL1_HUMAN (1-191): 1.09e-51: 165: 89.53