Protein: SPRE2
Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)

Gene: SPRE2, SPRED2
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q7Z698

Gene Ontology (top 5):
GO:0005173 - stem cell factor receptor binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0010719 - negative regulation of epithelial to mesenchymal transition
GO:0019901 - protein kinase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1279585

SPG21
Maspardin

4

1

High-throughput

0.698

High

1107869

SQSTM
Sequestosome-1

3

3

Small-scale

0.670

High

1279563

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

15

High-throughput

0.665

High

1279564

DPP9
Dipeptidyl peptidase 9

2

1

High-throughput

0.628

High

1128766

NBR1
Next to BRCA1 gene 1 protein

2

2

Small-scale

0.624

High

908136

KS6A3
Ribosomal protein S6 kinase alpha-3

2

7

High-throughput

0.621

High

715921

AQP1
Aquaporin-1

2

3

High-throughput

0.606

High

948349

KR122
Keratin-associated protein 12-2

2

20

High-throughput

0.606

High

968641

NCS1
Neuronal calcium sensor 1

2

8

High-throughput

0.606

High

979417

VISL1
Visinin-like protein 1

2

8

High-throughput

0.606

High

1279578

TSNAX
Translin-associated protein X

2

1

High-throughput

0.606

High

1279586

KCIP1
A-type potassium channel modulatory protein KCNIP1

2

8

High-throughput

0.606

High

1279588

KS6A6
Ribosomal protein S6 kinase alpha-6

2

7

High-throughput

0.606

High

992444

GBG5

2

0

High-throughput

0.602

High

1279567

ZDH17
Palmitoyltransferase ZDHHC17

2

14

High-throughput

0.591

High

375666

RASK
GTPase KRas

2

11

High-throughput

0.584

High

868198

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.580

High

1279587

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

2

1

High-throughput

0.574

High

159077

LCE2B
Late cornified envelope protein 2B

2

1

High-throughput

0.553

High

585060

ZN250
Zinc finger protein 250

2

2

High-throughput

0.553

High

605466

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

2

1

High-throughput

0.553

High

1213764

KPRP
Keratinocyte proline-rich protein

2

2

High-throughput

0.553

High

1213907

LCE1C
Late cornified envelope protein 1C

2

7

High-throughput

0.553

High

1215939

LCE5A
Late cornified envelope protein 5A

2

1

High-throughput

0.553

High

1279565

ZN575
Zinc finger protein 575

2

11

High-throughput

0.553

High

1279570

ZN417
Zinc finger protein 417

2

9

High-throughput

0.553

High

1279575

ZN837
Zinc finger protein 837

2

7

High-throughput

0.553

High

1279576

ZN414
Zinc finger protein 414

2

2

High-throughput

0.553

High

1279579

MDFI
MyoD family inhibitor

2

2

High-throughput

0.553

High

1115776

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.541

High

1279582

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

0

Small-scale

0.537

High

125844

AP4M1
AP-4 complex subunit mu-1

1

1

High-throughput

0.536

High

1146430

KS6A2
Ribosomal protein S6 kinase alpha-2

1

7

High-throughput

0.536

High

1279584

PRDC1
Phosphoribosyltransferase domain-containing protein 1

1

1

High-throughput

0.536

High

385903

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.515

High

570478

GFAP
Glial fibrillary acidic protein

1

1

High-throughput

0.515

High

650259

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.515

High

702468

CLAT
Choline O-acetyltransferase

1

2

High-throughput

0.515

High

705437

GRN
Progranulin

1

4

High-throughput

0.515

High

713111

NOS3
Nitric oxide synthase 3

1

1

High-throughput

0.515

High

843712

HD
Huntingtin

1

3

High-throughput

0.515

High

896806

DYN2
Dynamin-2

1

3

High-throughput

0.515

High

954519

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.515

High

1199323

GLE1
mRNA export factor GLE1

1

1

High-throughput

0.515

High

1279580

KRA24
Keratin-associated protein 2-4

1

20

High-throughput

0.515

High

690283

STOM
Stomatin

1

0

High-throughput

0.513

High

893499

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

0

High-throughput

0.513

High

1279569

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.513

High

1279574

F162A
Protein FAM162A

1

0

High-throughput

0.513

High

1279581

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

1

0

High-throughput

0.513

High

1279583

PPCS
Phosphopantothenate--cysteine ligase

1

0

High-throughput

0.513

High

456247

CATD
Cathepsin D

1

3

Small-scale

0.501

High

697933

CALR
Calreticulin

1

0

High-throughput

0.493

High

788085

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

317343

ACL6B
Actin-like protein 6B

1

10

High-throughput

0.489

High

662788

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

1

2

High-throughput

0.489

High

1279566

ZDH13
Palmitoyltransferase ZDHHC13

1

14

High-throughput

0.489

High

505347

KRA23
Keratin-associated protein 2-3

1

20

High-throughput

0.481

High

845700

MUC18
Cell surface glycoprotein MUC18

1

8

High-throughput

0.479

High

978123

RHOB
Rho-related GTP-binding protein RhoB

1

12

High-throughput

0.479

High

1150277

TESK1
Dual specificity testis-specific protein kinase 1

1

6

Small-scale

0.479

High

1279568

FBXW8
F-box/WD repeat-containing protein 8

1

1

High-throughput

0.479

High

1279589

ALK
ALK tyrosine kinase receptor

1

8

High-throughput

0.479

High

47360

A0A6Q8PF08
Peripheral myelin protein 22

1

2

High-throughput

0.470

High

109440

G5E9A7
DM1 locus, WD repeat containing

1

4

High-throughput

0.470

High

246010

KIF1B
Kinesin-like protein KIF1B

1

7

High-throughput

0.470

High

301520

WFS1
Wolframin

1

3

High-throughput

0.470

High

622201

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.470

High

1279571

NEK7
Serine/threonine-protein kinase Nek7

1

5

High-throughput

0.470

High

1279573

APBB2
Amyloid beta precursor protein binding family B member 2

1

4

High-throughput

0.470

High

1279577

MY15B
Unconventional myosin-XVB

1

2

High-throughput

0.470

High

1279590

RNF11
RING finger protein 11

1

1

High-throughput

0.470

High

533705

CLUS
Clusterin

1

1

High-throughput

0.457

High

651374

CBL
E3 ubiquitin-protein ligase CBL

1

12

Small-scale

0.445

High

1279572

CTL1
Choline transporter-like protein 1

1

1

High-throughput

0.445

High

352477

TOP3B
DNA topoisomerase 3-beta-1

2

0

High-throughput

0.327

High

1209142

RBM48
RNA-binding protein 48

2

0

High-throughput

0.316

High

65775

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.279

Low

1162399

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025