Protein: SPY3
Protein sprouty homolog 3 (Spry-3) (Sprouty RTK signaling antagonist 3) (Sprouty3)

Gene: SPY3, SPRY3
Organism: Homo sapiens
Interactions: 34
UniProt ID: O43610

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0007399 - nervous system development
GO:0016020 - membrane
GO:0040037 - negative regulation of fibroblast growth factor receptor signaling pathway
GO:0043409 - negative regulation of MAPK cascade

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

221408

KRT34
Keratin, type I cuticular Ha4

2

2

High-throughput

0.606

High

221412

VISL1
Visinin-like protein 1

2

8

High-throughput

0.606

High

221420

LCE1A
Late cornified envelope protein 1A

2

3

High-throughput

0.606

High

221430

LCE3D
Late cornified envelope protein 3D

2

6

High-throughput

0.606

High

221432

NEK6
Serine/threonine-protein kinase Nek6

2

2

High-throughput

0.606

High

221433

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

2

2

High-throughput

0.606

High

221427

S39A7
Zinc transporter SLC39A7

2

0

High-throughput

0.580

High

159030

LCE2B
Late cornified envelope protein 2B

2

1

High-throughput

0.553

High

221407

MABP1
Mitogen-activated protein kinase-binding protein 1

2

2

High-throughput

0.553

High

221409

AQP1
Aquaporin-1

2

3

High-throughput

0.553

High

221410

HXA1
Homeobox protein Hox-A1

2

16

High-throughput

0.553

High

221414

CREB5
Cyclic AMP-responsive element-binding protein 5

2

4

High-throughput

0.553

High

221417

LCE3E
Late cornified envelope protein 3E

2

6

High-throughput

0.553

High

221418

KPRP
Keratinocyte proline-rich protein

2

2

High-throughput

0.553

High

221419

LCE1F
Late cornified envelope protein 1F

2

3

High-throughput

0.553

High

221421

LCE1B
Late cornified envelope protein 1B

2

6

High-throughput

0.553

High

221422

LCE3A
Late cornified envelope protein 3A

2

3

High-throughput

0.553

High

221424

ZDH17
Palmitoyltransferase ZDHHC17

2

10

High-throughput

0.553

High

221425

ZN655
Zinc finger protein 655

2

6

High-throughput

0.553

High

221426

CTSR1
Cation channel sperm-associated protein 1

2

4

High-throughput

0.553

High

221428

ZN587
Zinc finger protein 587

2

8

High-throughput

0.553

High

221429

BEX2
Protein BEX2

2

3

High-throughput

0.553

High

221431

CHRD
Chordin

2

8

High-throughput

0.553

High

221434

R3HD2
R3H domain-containing protein 2

2

2

High-throughput

0.553

High

221061

SPY2
Protein sprouty homolog 2

1

15

Small-scale

0.479

High

221406

SPY3
Protein sprouty homolog 3

1

14

Small-scale

0.479

High

221413

GRB2
Growth factor receptor-bound protein 2

1

15

Small-scale

0.479

High

221415

SOS1
Son of sevenless homolog 1

1

5

Small-scale

0.479

High

221416

TESK1
Dual specificity testis-specific protein kinase 1

1

6

Small-scale

0.479

High

221423

Q6FHY5
MEOX2 protein

1

11

High-throughput

0.470

High

221411

MEOX2
Homeobox protein MOX-2

1

10

High-throughput

0.439

High

221013

HAIR
Lysine-specific demethylase hairless

2

0

High-throughput

0.316

High

221435

GPSM3
G-protein-signaling modulator 3

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025