HitPredict

Interactor 1: I22R2 (Q969J5)
Interleukin-22 receptor subunit alpha-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (Cytokine receptor class-II member 10) (Cytokine receptor family 2 member 10) (CRF2-10) (Cytokine receptor family type 2, soluble 1) (CRF2-S1) (Interleukin-22-binding protein) (IL-22BP) (IL22BP) (ZcytoR16)
Gene: IL22RA2

Interactor 2: IL22 (Q9GZX6)
Interleukin-22 (IL-22) (Cytokine Zcyto18) (IL-10-related T-cell-derived-inducible factor) (IL-TIF)
Gene: IL22

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	11390453, 18599299, 19193995, 19285080, 15120653
Identification Methods	pull down, surface plasmon resonance, x-ray crystallography, enzyme linked immunosorbent assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	IL22~Interfer-bind, IL22~Tissue_fac
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0050728 - negative regulation of inflammatory response
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 263 Hs			1 179
+	Mm
		1194454 I22R2_MOUSE (1-263): 5.43e-84: 252: 57.41		IL22_MOUSE (1-179): 2.77e-113: 321: 78.21
+	Hs
		1236245 I22R1_HUMAN (13-263): 1.71e-51: 178: 27.34		IL22_HUMAN (1-179): 5.46e-115: 325: 100.00
+	Hs
		994628 I10R2_HUMAN (29-259): 2.1e-51: 172: 22.85		IL22_HUMAN (1-179): 5.46e-115: 325: 100.00