HitPredict

Interactor 1: WBP2 (Q969T9)
WW domain-binding protein 2 (WBP-2)
Gene: WBP2

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	27578003, 9169421, 28461335, 31340145, 33961781
Identification Methods	two hybrid, unspecified method, enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 922
+	Hs
		1282371 WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125630 WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		1282372 WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		808210 WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		1192157 WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00		HUWE1_HUMAN (130-921): 1.4e-172: 559: 24.48
+	Mm
		808347 WBP2_MOUSE (1-261): 1.95e-70: 218: 96.94		NEDD4_MOUSE (3-446): 4.73e-51: 195: 18.83
+	Ce
		1090426 Q18966_CAEEL (1-231): 7.38e-52: 170: 32.64		WWP1_CAEEL (12-420): 4.03e-32: 136: 17.52