Interactor 1: TIFA (Q96CG3)
TRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein)
Gene: TIFA
Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.90 | 0.60 | 0.737 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 30378729, 36098982, 27107012, 12566447, 36965415, 26068852 |
| Identification Methods | pull down, x-ray crystallography, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, barcode fusion genetics two hybrid, validated two hybrid |
| Interaction Type | direct interaction, association, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007249 - canonical NF-kappaB signal transduction GO:0033209 - tumor necrosis factor-mediated signaling pathway and 2 others more... |
| Homologous interactions | 7 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
