Protein: FOXM1
Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells)

Gene: FOXM1
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q08050

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1045215

TF65
Transcription factor p65

2

13

Small-scale

0.754

High

919909

PLK1
Serine/threonine-protein kinase PLK1

5

5

Small-scale

0.716

High

1061603

CBP
CREB-binding protein

5

16

Small-scale

0.716

High

1061628

FZR1
Fizzy-related protein homolog

5

9

Small-scale

0.702

High

443333

CDK1
Cyclin-dependent kinase 1

4

5

Small-scale

0.698

High

573808

CCNB1
G2/mitotic-specific cyclin-B1

4

2

Small-scale

0.683

High

1061609

OTUB1
Ubiquitin thioesterase OTUB1

4

0

Small-scale

0.667

High

667803

CDK2
Cyclin-dependent kinase 2

3

5

Small-scale

0.656

High

519491

MYBB
Myb-related protein B

3

3

Small-scale

0.656

High

764697

CTNB1
Catenin beta-1

2

5

Small-scale

0.650

High

666978

CCNE1
G1/S-specific cyclin-E1

2

2

Small-scale

0.639

High

442684

RB
Retinoblastoma-associated protein

2

6

Small-scale

0.634

High

1061608

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

3

Small-scale

0.624

High

219724

FOXO3
Forkhead box protein O3

1

19

Small-scale

0.618

High

1061600

BANP
Protein BANP

2

1

High-throughput

0.613

High

1061625

FBXL2
F-box/LRR-repeat protein 2

3

2

Small-scale

0.599

High

1061588

LIN9
Protein lin-9 homolog

2

0

Small-scale

0.585

High

718550

CDC27
Cell division cycle protein 27 homolog

2

2

Small-scale

0.584

High

853460

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

2

8

Small-scale

0.584

High

1061624

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

Small-scale

0.578

High

1061574

FOXM1
Forkhead box protein M1

1

17

High-throughput

0.575

High

464933

SP1
Transcription factor Sp1

1

13

Small-scale

0.561

High

583857

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

5

Small-scale

0.561

High

1014483

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.561

High

1061585

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

10

Small-scale

0.561

High

1061606

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

Small-scale

0.561

High

1061627

RN112
RING finger protein 112

1

3

Small-scale

0.561

High

1061631

DCAF1
DDB1- and CUL4-associated factor 1

1

6

Small-scale

0.561

High

139521

PESC
Pescadillo homolog

1

1

High-throughput

0.554

High

1061577

ORC2
Origin recognition complex subunit 2

1

3

High-throughput

0.554

High

1061617

TF7L2
Transcription factor 7-like 2

1

20

Small-scale

0.554

High

549130

CDK4
Cyclin-dependent kinase 4

1

7

Small-scale

0.550

High

1025330

CDK6
Cyclin-dependent kinase 6

1

7

Small-scale

0.550

High

1061614

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

17

High-throughput

0.541

High

212216

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

High-throughput

0.536

High

222972

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.536

High

243611

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.536

High

289509

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

9

High-throughput

0.536

High

333997

SMC2
Structural maintenance of chromosomes protein 2

1

17

High-throughput

0.536

High

794450

RBMX
RNA-binding motif protein, X chromosome

1

7

High-throughput

0.536

High

834434

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

15

High-throughput

0.536

High

868143

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.536

High

928431

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.536

High

1061579

BMS1
Ribosome biogenesis protein BMS1 homolog

1

2

High-throughput

0.536

High

1061580

KIF22
Kinesin-like protein KIF22

1

2

High-throughput

0.536

High

1061592

LIN54
Protein lin-54 homolog

1

1

High-throughput

0.536

High

1061593

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.536

High

1061598

KAISO
Transcriptional regulator Kaiso

1

4

High-throughput

0.536

High

1061602

DNJC9
DnaJ homolog subfamily C member 9

1

4

High-throughput

0.536

High

1061615

ECT2
Protein ECT2

1

1

High-throughput

0.536

High

1061622

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

3

High-throughput

0.536

High

1061626

TF3C4
General transcription factor 3C polypeptide 4

1

4

High-throughput

0.536

High

1061629

DDX52
Probable ATP-dependent RNA helicase DDX52

1

5

High-throughput

0.536

High

272914

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.530

High

719214

MPIP2
M-phase inducer phosphatase 2

1

1

Small-scale

0.515

High

1061586

DEP1A
DEP domain-containing protein 1A

1

0

High-throughput

0.513

High

1061587

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.513

High

1061597

TRM1L
tRNA

1

0

High-throughput

0.513

High

1061601

KI18A
Kinesin-like protein KIF18A

1

0

High-throughput

0.513

High

1061610

LIN37
Protein lin-37 homolog

1

0

High-throughput

0.513

High

1061613

PAR6B
Partitioning defective 6 homolog beta

1

0

High-throughput

0.513

High

576756

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.506

High

354956

CHK2
Serine/threonine-protein kinase Chk2

1

4

Small-scale

0.501

High

991307

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.501

High

993524

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.501

High

1061584

HIF1A
Hypoxia-inducible factor 1-alpha

1

11

Small-scale

0.501

High

47007

PNT87
Transcriptional regulator PINT87aa

1

0

Small-scale

0.493

High

549574

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.489

High

1061620

SYLC
Leucine--tRNA ligase, cytoplasmic

1

15

High-throughput

0.489

High

1061623

HERC5
E3 ISG15--protein ligase HERC5

1

5

High-throughput

0.489

High

129009

MEN1
Menin

1

6

High-throughput

0.479

High

142965

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

302496

RNF8
E3 ubiquitin-protein ligase RNF8

1

4

Small-scale

0.479

High

371858

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.479

High

413703

P53
Cellular tumor antigen p53

1

14

High-throughput

0.479

High

461401

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.479

High

468300

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

473943

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

542477

TOP2A
DNA topoisomerase 2-alpha

1

3

Small-scale

0.479

High

587063

ITF2
Transcription factor 4

1

1

Small-scale

0.479

High

714063

PML
Protein PML

1

6

High-throughput

0.479

High

719133

MPIP1
M-phase inducer phosphatase 1

1

1

Small-scale

0.479

High

891137

GSK3A
Glycogen synthase kinase-3 alpha

1

3

Small-scale

0.479

High

891488

GSK3B
Glycogen synthase kinase-3 beta

1

4

Small-scale

0.479

High

980720

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1061575

EP300
Histone acetyltransferase p300

1

18

Small-scale

0.479

High

1061576

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1061581

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1061582

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

Small-scale

0.479

High

1061591

OTU7B
OTU domain-containing protein 7B

1

5

Small-scale

0.479

High

1061594

FXL19
F-box/LRR-repeat protein 19

1

4

Small-scale

0.479

High

1061599

RN168
E3 ubiquitin-protein ligase RNF168

1

1

Small-scale

0.479

High

1061605

IRF7
Interferon regulatory factor 7

1

4

Small-scale

0.479

High

1061607

FBXW7
F-box/WD repeat-containing protein 7

1

12

Small-scale

0.479

High

1061612

TRI56
E3 ubiquitin-protein ligase TRIM56

1

7

Small-scale

0.479

High

1061630

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

1061632

PARP3
Protein mono-ADP-ribosyltransferase PARP3

1

7

Small-scale

0.479

High

162937

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.458

High

181094

AXIN1
Axin-1

1

0

Small-scale

0.458

High

832698

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.458

High

1061583

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

1061604

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.458

High

1061621

DNM3B
DNA

1

0

Small-scale

0.458

High

75862

B4DE54
Protein BANP

1

1

High-throughput

0.457

High

1061595

ANR12
Ankyrin repeat domain-containing protein 12

1

6

Small-scale

0.445

High

1061611

LZTS2
Leucine zipper putative tumor suppressor 2

1

3

High-throughput

0.437

High

1061616

GORS2
Golgi reassembly-stacking protein 2

1

5

Small-scale

0.437

High

1061618

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

15

High-throughput

0.437

High

1061619

SLX9
Ribosome biogenesis protein SLX9 homolog

1

1

Small-scale

0.437

High

58807

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.407

High

596473

CTLA4
Cytotoxic T-lymphocyte protein 4

2

0

High-throughput

0.313

High

1061589

FBX31
F-box only protein 31

2

0

Small-scale

0.305

High

190346

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

391231

FRIL
Ferritin light chain

1

0

High-throughput

0.279

Low

518834

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.279

Low

1061596

SYPM
Probable proline--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1061578

OS9
Protein OS-9

1

0

High-throughput

0.251

Low

1061590

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

239042

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025