Protein: KAISO
Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)

Gene: KAISO, ZBTB33
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q86T24

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

254174

CTND1
Catenin delta-1

11

6

Small-scale

0.758

High

1286808

FXL17
F-box/LRR-repeat protein 17

2

1

Small-scale

0.737

High

1286767

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

5

20

High-throughput

0.721

High

1047608

NOTC2
Neurogenic locus notch homolog protein 2

1

20

High-throughput

0.691

High

1199556

KLH22
Kelch-like protein 22

1

1

High-throughput

0.691

High

964351

SUMO2
Small ubiquitin-related modifier 2

4

3

High-throughput

0.690

High

414118

P53
Cellular tumor antigen p53

3

9

Small-scale

0.640

High

1248821

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

3

0

High-throughput

0.638

High

1286797

ZN576
Zinc finger protein 576

2

20

High-throughput

0.628

High

1286804

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.628

High

278376

NCOR1
Nuclear receptor corepressor 1

2

10

Small-scale

0.625

High

247369

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

3

High-throughput

0.618

High

1113553

CUL3
Cullin-3

1

20

High-throughput

0.618

High

1286771

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

4

High-throughput

0.618

High

568664

GYS1
Glycogen [starch] synthase, muscle

2

1

High-throughput

0.606

High

939204

SUMO3
Small ubiquitin-related modifier 3

2

3

High-throughput

0.606

High

1286800

TRPV5
Transient receptor potential cation channel subfamily V member 5

1

0

High-throughput

0.586

High

714232

PML
Protein PML

2

20

High-throughput

0.584

High

945515

GSDMD
Gasdermin-D

2

0

High-throughput

0.580

High

1286787

NUD22
Uridine diphosphate glucose pyrophosphatase NUDT22

2

0

High-throughput

0.580

High

552999

PIP
Prolactin-inducible protein

2

0

High-throughput

0.576

High

1030795

DEF5
Defensin alpha 5

2

1

High-throughput

0.574

High

1286778

VWCE
von Willebrand factor C and EGF domain-containing protein

2

20

High-throughput

0.574

High

764867

CTNB1
Catenin beta-1

1

10

Small-scale

0.561

High

1100067

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.561

High

1286801

TF7L2
Transcription factor 7-like 2

1

14

Small-scale

0.561

High

270257

MTG16
Protein CBFA2T3

1

2

Small-scale

0.552

High

1121964

ARHG7
Rho guanine nucleotide exchange factor 7

2

0

High-throughput

0.547

High

285979

SF3B1
Splicing factor 3B subunit 1

1

6

High-throughput

0.536

High

288109

FOXH1
Forkhead box protein H1

1

8

High-throughput

0.536

High

549630

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

3

High-throughput

0.536

High

660107

COF1
Cofilin-1

1

1

High-throughput

0.536

High

937642

FOXG1
Forkhead box protein G1

1

3

High-throughput

0.536

High

938018

FOXA3
Hepatocyte nuclear factor 3-gamma

1

3

High-throughput

0.536

High

1061598

FOXM1
Forkhead box protein M1

1

4

High-throughput

0.536

High

1286769

WDR48
WD repeat-containing protein 48

1

2

High-throughput

0.536

High

1286784

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

1

High-throughput

0.536

High

1286786

FOXB1
Forkhead box protein B1

1

6

High-throughput

0.536

High

1286789

KLF16
Krueppel-like factor 16

1

19

High-throughput

0.536

High

1286791

FOXP3
Forkhead box protein P3

1

3

High-throughput

0.536

High

1286792

FOXQ1
Forkhead box protein Q1

1

7

High-throughput

0.536

High

1286803

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.536

High

1286806

FBLN5
Fibulin-5

1

20

High-throughput

0.536

High

1087836

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.515

High

1133500

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.515

High

166166

AIM2
Interferon-inducible protein AIM2

1

0

High-throughput

0.513

High

539717

ACHB
Acetylcholine receptor subunit beta

1

0

High-throughput

0.513

High

570924

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

1286770

TM10A
tRNA methyltransferase 10 homolog A

1

0

High-throughput

0.513

High

1286779

SGF29
SAGA-associated factor 29

1

0

High-throughput

0.513

High

1286780

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

1286802

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.513

High

1254132

CAN12
Calpain-12

1

1

High-throughput

0.489

High

1286788

DPH7
Diphthine methyltransferase

1

3

High-throughput

0.489

High

143086

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

188317

HDAC3
Histone deacetylase 3

1

6

Small-scale

0.479

High

246719

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.479

High

342235

BRD1
Bromodomain-containing protein 1

1

5

High-throughput

0.479

High

355550

NSD2
Histone-lysine N-methyltransferase NSD2

1

6

Small-scale

0.479

High

372443

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

385909

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

14

High-throughput

0.479

High

474096

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

520171

ANDR
Androgen receptor

1

18

High-throughput

0.479

High

537433

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

558237

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

606883

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.479

High

655856

TBG1
Tubulin gamma-1 chain

1

2

High-throughput

0.479

High

685025

DNMT1
DNA

1

3

Small-scale

0.479

High

695832

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

728318

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.479

High

730723

1433S
14-3-3 protein sigma

1

20

Small-scale

0.479

High

768543

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

830996

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

851600

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.479

High

862266

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.479

High

886522

CTCF
Transcriptional repressor CTCF

1

15

Small-scale

0.479

High

910969

IMA1
Importin subunit alpha-1

1

9

Small-scale

0.479

High

966547

1433G
14-3-3 protein gamma

1

20

Small-scale

0.479

High

971716

1433E
14-3-3 protein epsilon

1

2

Small-scale

0.479

High

990424

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

1004774

RNF4
E3 ubiquitin-protein ligase RNF4

1

15

High-throughput

0.479

High

1008790

RED1
Double-stranded RNA-specific editase 1

1

9

High-throughput

0.479

High

1045458

TF65
Transcription factor p65

1

3

Small-scale

0.479

High

1067468

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

1109850

HDAC1
Histone deacetylase 1

1

7

High-throughput

0.479

High

1139751

SETB1
Histone-lysine N-methyltransferase SETDB1

1

5

Small-scale

0.479

High

1151754

RHOH
Rho-related GTP-binding protein RhoH

1

2

Small-scale

0.479

High

1216127

FHL5
Four and a half LIM domains protein 5

1

12

High-throughput

0.479

High

1276423

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1280320

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1281546

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

1286765

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1286766

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1286774

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

1286775

KAT5
Histone acetyltransferase KAT5

1

3

Small-scale

0.479

High

1286776

LRC59
Leucine-rich repeat-containing protein 59

1

7

High-throughput

0.479

High

1286777

PF21A
PHD finger protein 21A

1

17

High-throughput

0.479

High

1286782

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1286783

CIC
Protein capicua homolog

1

12

High-throughput

0.479

High

1286785

TBX5
T-box transcription factor TBX5

1

4

High-throughput

0.479

High

1286790

PCGF6
Polycomb group RING finger protein 6

1

5

High-throughput

0.479

High

1286793

WWTR1
WW domain-containing transcription regulator protein 1

1

7

High-throughput

0.479

High

1286795

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1286796

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

Small-scale

0.479

High

1286805

DNM3B
DNA

1

2

Small-scale

0.479

High

1286807

TRI10
Tripartite motif-containing protein 10

1

20

High-throughput

0.479

High

1286809

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

1286810

CTND2
Catenin delta-2

1

6

Small-scale

0.479

High

1286811

DNM3A
DNA

1

2

Small-scale

0.479

High

399991

CATA
Catalase

1

0

High-throughput

0.458

High

519397

MYB
Transcriptional activator Myb

1

0

High-throughput

0.458

High

642952

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

867251

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

1286772

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.458

High

1286773

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

1286794

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.458

High

1286798

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1243619

S27A1
Long-chain fatty acid transport protein 1

1

1

High-throughput

0.445

High

1286768

RN169
E3 ubiquitin-protein ligase RNF169

1

16

Small-scale

0.445

High

293942

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

1025929

NDP
Norrin

1

1

Small-scale

0.437

High

1063385

GOGA2
Golgin subfamily A member 2

1

15

High-throughput

0.437

High

1071171

ARL16
ADP-ribosylation factor-like protein 16

1

4

High-throughput

0.437

High

1286799

XAGE1
X antigen family member 1

2

0

High-throughput

0.313

High

777248

ALS
Insulin-like growth factor-binding protein complex acid labile subunit

1

0

High-throughput

0.279

Low

1286781

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.279

Low

1286812

CCD61
Centrosomal protein CCDC61

1

0

High-throughput

0.279

Low

458641

PGS2
Decorin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025