HitPredict

Interactor 1: RIMS1 (Q86UR5)
Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)
Gene: RIMS1

Interactor 2: RB6I2 (Q8IUD2)
ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)
Gene: ERC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031267 - small GTPase binding GO:0042734 - presynaptic membrane GO:0098831 - presynaptic active zone cytoplasmic component GO:0098882 - structural constituent of presynaptic active zone
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1692 Hs			1 1116
+	Hs
		1141745 RIMS1_HUMAN (1-1692): 0: 976: 100.00		EEA1_HUMAN (7-578): 4.73e-23: 108: 9.29
+	Hs
		177122 RIMS1_HUMAN (1-1692): 0: 976: 100.00		ERC2_HUMAN (512-1116): 3.42e-22: 105: 12.75
+	Hs
		772886 RIMS1_HUMAN (1-1692): 0: 976: 100.00		MYH9_HUMAN (771-1116): 1.24e-15: 84.8: 10.12
+	Hs
		773219 RIMS1_HUMAN (1-1692): 0: 976: 100.00		MYH10_HUMAN (2-407): 8.75e-12: 72.1: 9.98
+	Rn
		1283532 RIMS1_RAT (1-1692): 0: 809: 79.43		RB6I2_RAT (472-1116): 2.04e-21: 102: 11.70
+	Dm
		68171 Q9V483_DROME (854-1691): 1.86e-65: 249: 10.81		A8DY79_DROME (153-902): 3.28e-24: 112: 23.90
+	Rn
		1283533 RIMS2_RAT (313-1692): 1.24e-68: 258: 29.81		RB6I2_RAT (472-1116): 2.04e-21: 102: 11.70
+	Hs
		177132 UN13A_HUMAN (1006-1691): 1.55e-59: 229: 11.98		ERC2_HUMAN (512-1116): 3.42e-22: 105: 12.75
+	Hs
		1141786 UN13C_HUMAN (315-1691): 5.18e-54: 211: 10.92		EEA1_HUMAN (7-578): 4.73e-23: 108: 9.29
+	Hs
		1141667 SYT6_HUMAN (435-887): 1.62e-55: 204: 15.34		EEA1_HUMAN (7-578): 4.73e-23: 108: 9.29
+	Hs
		157527 SYT10_HUMAN (462-896): 3.47e-48: 183: 18.14		CTRO_HUMAN (156-758): 7.78e-19: 95.1: 14.09
+	Hs
		1122787 DOC2A_HUMAN (744-875): 1.08e-30: 128: 28.79		EEA1_HUMAN (7-578): 4.73e-23: 108: 9.29
+	Hs
		177134 PCLO_HUMAN (1446-1666): 1.18e-29: 131: 21.37		ERC2_HUMAN (512-1116): 3.42e-22: 105: 12.75
+	Hs
		158047 PCLO_HUMAN (1446-1666): 1.18e-29: 131: 21.37		CTRO_HUMAN (156-758): 7.78e-19: 95.1: 14.09
+	Ce
		232339 UNC13_CAEEL (898-1662): 6.43e-35: 148: 11.74		O44490_CAEEL (161-834): 3.61e-09: 63.2: 20.15
+	Hs
		1142027 RIMS2_HUMAN (275-869): 8.47e-17: 89.3: 13.86		EEA1_HUMAN (7-578): 4.73e-23: 108: 9.29
+	Hs
		135894 P3C2A_HUMAN (1538-1664): 1.27e-23: 111: 27.48		MYH9_HUMAN (771-1116): 1.24e-15: 84.8: 10.12
+	Hs
		135971 P3C2A_HUMAN (1538-1664): 1.27e-23: 111: 27.48		MY18A_HUMAN (439-976): 3.59e-09: 63.5: 18.73
+	Hs
		297328 DYSF_HUMAN (1553-1686): 4.37e-15: 83.5: 20.00		MYH3_HUMAN (690-1116): 1.51e-13: 77.8: 12.33
+	Hs
		773281 SYTL2_HUMAN (879-1657): 1.42e-13: 78.4: 11.60		MYH10_HUMAN (2-407): 8.75e-12: 72.1: 9.98