HitPredict

Interactor 1: RIMS1 (Q86UR5)
Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)
Gene: RIMS1

Interactor 2: BSN (Q9UPA5)
Protein bassoon (Zinc finger protein 231)
Gene: BSN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	14734538, 37207277
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008270 - zinc ion binding GO:0048786 - presynaptic active zone GO:0098882 - structural constituent of presynaptic active zone
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1692 Hs			1 3926
+	Hs
		1462448 UN13A_HUMAN (1006-1691): 1.55e-59: 229: 11.98		BSN_HUMAN (1-3926): 0: 1696: 100.00
+	Hs
		1288961 RIMS1_HUMAN (1-1692): 0: 976: 100.00		PCLO_HUMAN (2-1549): 8.48e-10: 67.9: 8.56
+	Dm
		1303209 Q8IM87_DROME (854-1691): 3.47e-62: 238: 11.31		Q9VLS7_DROME (64-789): 1.92e-09: 66.4: 15.46
+	Mm
		1455913 PCLO_MOUSE (1446-1663): 1.88e-29: 131: 21.65		PCLO_MOUSE (3649-3916): 1.02e-10: 71: 15.24
+	Hs
		297365 DYSF_HUMAN (1553-1686): 4.37e-15: 83.5: 20.00		TITIN_HUMAN (1049-2709): 6.96e-23: 111: 7.73
+	Mm
		1424398 RIMS2_MOUSE (275-869): 1.64e-17: 91.6: 14.59		PCLO_MOUSE (3649-3916): 1.02e-10: 71: 15.24
+	Hs
		639120 SYT1_HUMAN (744-872): 2.39e-18: 91.5: 21.13		ANK2_HUMAN (56-1331): 5.36e-10: 68.2: 10.73