HitPredict - High confidence protein-protein interactions

Interactor 1: SYT5 (O00445)
Synaptotagmin-5 (Synaptotagmin V) (SytV)
Gene: SYT5

Interactor 2: SYT1 (P21579)
Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65)
Gene: SYT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C2~C2
Common GO terms	GO:0001786 - phosphatidylserine binding GO:0005509 - calcium ion binding GO:0005544 - calcium-dependent phospholipid binding GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding GO:0005886 - plasma membrane and 13 others more... GO:0007268 - chemical synaptic transmission GO:0014059 - regulation of dopamine secretion GO:0017158 - regulation of calcium ion-dependent exocytosis GO:0019905 - syntaxin binding GO:0030276 - clathrin binding GO:0030424 - axon GO:0030672 - synaptic vesicle membrane GO:0031045 - dense core granule GO:0046982 - protein heterodimerization activity GO:0048488 - synaptic vesicle endocytosis GO:0048791 - calcium ion-regulated exocytosis of neurotransmitter GO:0070382 - exocytic vesicle GO:0071277 - cellular response to calcium ion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	386
Hs

1	422

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Last updated: 15 Jul 2024