HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1055
+	Hs
		129297 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA7_HUMAN (6-982): 0: 1154: 57.46
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (16-980): 0: 1152: 56.37
+	Hs
		129253 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA4_HUMAN (6-982): 0: 1152: 58.33
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (6-984): 0: 1148: 56.69
+	Hs
		129210 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA8_HUMAN (20-982): 0: 1066: 50.71
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (18-980): 0: 1041: 47.98
+	Hs
		129198 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA1_HUMAN (12-976): 0: 961: 41.21
+	Hs
		872468 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA5_HUMAN (6-984): 0: 1148: 56.69
+	Hs
		665299 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA2_HUMAN (18-980): 0: 1041: 47.98
+	Hs
		129162 P85B_HUMAN (1-728): 0: 549: 100.00		INSR_HUMAN (277-941): 5.94e-150: 484: 24.02
+	Hs
		129189 P85B_HUMAN (1-728): 0: 549: 100.00		INSRR_HUMAN (283-914): 7.43e-149: 479: 25.23
+	Hs
		129215 P85B_HUMAN (1-728): 0: 549: 100.00		UFO_HUMAN (266-950): 2.71e-152: 477: 23.12
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (347-885): 2.31e-146: 474: 27.31
+	Mm
		140060 P85B_MOUSE (1-728): 0: 541: 88.87		UFO_MOUSE (266-933): 3.67e-153: 479: 23.81
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (392-932): 6.72e-145: 455: 22.69
+	Hs
		674489 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		UFO_HUMAN (266-950): 2.71e-152: 477: 23.12
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (347-885): 2.31e-146: 474: 27.31
+	Hs
		129173 P85B_HUMAN (1-728): 0: 549: 100.00		HCK_HUMAN (575-881): 7.23e-65: 230: 40.91
+	Hs
		433433 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		YES_HUMAN (572-881): 5.77e-65: 231: 42.95
+	Hs
		442864 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		HCK_HUMAN (575-881): 7.23e-65: 230: 40.91