HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 196
+	Hs
		129270 P85B_HUMAN (1-728): 0: 549: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		129262 P85B_HUMAN (1-728): 0: 549: 100.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		129190 P85B_HUMAN (1-728): 0: 549: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		129275 P85B_HUMAN (1-728): 0: 549: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		129259 P85B_HUMAN (1-728): 0: 549: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		129260 P85B_HUMAN (1-728): 0: 549: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		129193 P85B_HUMAN (1-728): 0: 549: 100.00		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120196 P85B_HUMAN (1-728): 0: 549: 100.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		900751 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		564631 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		855782 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		789055 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		855779 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		545245 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		411980 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		411948 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		855778 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		789050 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		789051 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		564442 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74