HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	35384245, 1330535
Identification Methods	proximity labelling technology, biophysical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1106
+	Hs
		129191 P85B_HUMAN (1-728): 0: 549: 100.00		PGFRA_HUMAN (3-1106): 0: 716: 42.48
+	Hs
		129178 P85B_HUMAN (1-728): 0: 549: 100.00		KIT_HUMAN (3-1003): 0: 601: 29.99
+	Mm
		140055 P85B_MOUSE (1-728): 0: 541: 88.87		KIT_MOUSE (24-1004): 0: 603: 31.01
+	Hs
		557215 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		PGFRA_HUMAN (3-1106): 0: 716: 42.48
+	Hs
		129299 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58
+	Mm
		140060 P85B_MOUSE (1-728): 0: 541: 88.87		UFO_MOUSE (129-1047): 8.28e-130: 419: 14.14
+	Hs
		499280 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		KIT_HUMAN (3-1003): 0: 601: 29.99
+	Hs
		129278 P85B_HUMAN (1-728): 0: 549: 100.00		ROR1_HUMAN (219-1095): 2.41e-113: 376: 14.94
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44
+	Ce
		106190 G5EDP9_CAEEL (318-717): 1.77e-95: 307: 26.27		EGL15_CAEEL (11-1064): 1.41e-153: 486: 16.68
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (9-326): 2.34e-58: 218: 11.51
+	Hs
		129225 P85B_HUMAN (1-728): 0: 549: 100.00		VGFR3_HUMAN (32-529): 2.63e-47: 187: 19.38
+	Hs
		499243 TXK_HUMAN (550-727): 8.04e-33: 135: 23.24		KIT_HUMAN (3-1003): 0: 601: 29.99
+	Hs
		129201 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73
+	Hs
		129215 P85B_HUMAN (1-728): 0: 549: 100.00		UFO_HUMAN (5-330): 1.39e-13: 77.6: 13.03
+	Hs
		129165 P85B_HUMAN (1-728): 0: 549: 100.00		CSF1R_HUMAN (10-385): 7.2e-13: 75.3: 12.97
+	Hs
		608065 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73
+	Hs
		674489 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		UFO_HUMAN (5-330): 1.39e-13: 77.6: 13.03
+	Dm
		112231 SRC42_DROME (551-727): 1.47e-35: 143: 22.78		M9MRE1_DROME (32-503): 7e-43: 173: 16.67
+	Dm
		112209 ABL_DROME (531-725): 1.27e-32: 138: 20.92		M9MRE1_DROME (32-503): 7e-43: 173: 16.67