HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 422
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (29-417): 7.84e-125: 382: 23.64
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (2-408): 7.62e-122: 378: 20.49
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (46-411): 2.25e-121: 377: 21.95
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (2-408): 4.94e-121: 377: 20.33
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (5-393): 2.02e-120: 376: 19.29
+	Hs
		129170 P85B_HUMAN (1-728): 0: 549: 100.00		RET_HUMAN (8-415): 2.01e-119: 375: 23.29
+	Hs
		129297 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA7_HUMAN (36-414): 1.44e-120: 375: 19.37
+	Hs
		129253 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73
+	Hs
		129201 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		129185 P85B_HUMAN (1-728): 0: 549: 100.00		SRC_HUMAN (90-390): 1.63e-110: 336: 28.95
+	Hs
		129164 P85B_HUMAN (1-728): 0: 549: 100.00		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Hs
		69198 P85B_HUMAN (1-728): 0: 549: 100.00		A9UF07_HUMAN (143-387): 7.57e-41: 157: 35.34
+	Hs
		129151 P85B_HUMAN (1-728): 0: 549: 100.00		ABL1_HUMAN (143-387): 8.6e-41: 156: 35.34
+	Hs
		665299 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA2_HUMAN (46-411): 2.25e-121: 377: 21.95
+	Hs
		608065 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		523089 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		SRC_HUMAN (90-390): 1.63e-110: 336: 28.95
+	Hs
		412285 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Hs
		433433 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		YES_HUMAN (88-390): 1.93e-108: 331: 28.76
+	Hs
		789082 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ABL2_HUMAN (143-381): 3.74e-40: 155: 36.63