Protein: DDX46
Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog)

Gene: DDX46
Organism: Homo sapiens
Interactions: 188
UniProt ID: Q7L014

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006494

SRPK2
SRSF protein kinase 2

6

16

High-throughput

0.736

High

973750

RUXE
Small nuclear ribonucleoprotein E

3

2

High-throughput

0.662

High

280685

PR40A
Pre-mRNA-processing factor 40 homolog A

3

20

High-throughput

0.660

High

485667

RU2A
U2 small nuclear ribonucleoprotein A'

3

5

High-throughput

0.650

High

1239616

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

7

High-throughput

0.628

High

1270800

ANR50
Ankyrin repeat domain-containing protein 50

1

1

High-throughput

0.618

High

626269

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

7

High-throughput

0.618

High

731414

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.618

High

854877

RECQ1
ATP-dependent DNA helicase Q1

1

19

High-throughput

0.618

High

1008783

RED1
Double-stranded RNA-specific editase 1

1

10

High-throughput

0.618

High

1088415

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

14

High-throughput

0.618

High

1128039

DHX8
ATP-dependent RNA helicase DHX8

1

13

High-throughput

0.618

High

1132780

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

14

High-throughput

0.618

High

1241664

PRP8
Pre-mRNA-processing-splicing factor 8

1

4

High-throughput

0.618

High

1270777

DDX23
Probable ATP-dependent RNA helicase DDX23

1

15

High-throughput

0.618

High

1113502

CUL3
Cullin-3

2

17

High-throughput

0.611

High

1270806

LC7L2
Putative RNA-binding protein Luc7-like 2

2

1

High-throughput

0.611

High

1145246

RNPS1
RNA-binding protein with serine-rich domain 1

2

18

High-throughput

0.601

High

129207

MEN1
Menin

2

4

High-throughput

0.584

High

242093

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.584

High

558228

XRCC6
X-ray repair cross-complementing protein 6

2

5

High-throughput

0.584

High

1148607

SF3A2
Splicing factor 3A subunit 2

2

6

Small-scale

0.584

High

396397

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

436693

KPCB
Protein kinase C beta type

2

3

High-throughput

0.571

High

787668

SPB5
Serpin B5

2

2

High-throughput

0.558

High

1254367

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

1270801

HECD1
E3 ubiquitin-protein ligase HECTD1

1

11

High-throughput

0.553

High

611908

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

733255

OTX2
Homeobox protein OTX2

1

2

High-throughput

0.536

High

876911

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.536

High

879728

MAPK2
MAP kinase-activated protein kinase 2

1

2

High-throughput

0.536

High

991352

SUMO1
Small ubiquitin-related modifier 1

1

5

High-throughput

0.536

High

1099711

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

1117583

NOG2
Nucleolar GTP-binding protein 2

1

5

High-throughput

0.536

High

1159979

SRSF7
Serine/arginine-rich splicing factor 7

1

15

High-throughput

0.536

High

1205844

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

8

High-throughput

0.536

High

1270760

EZH1
Histone-lysine N-methyltransferase EZH1

1

8

High-throughput

0.536

High

1270770

SRPK1
SRSF protein kinase 1

1

13

High-throughput

0.536

High

1270773

RBM4B
RNA-binding protein 4B

1

12

High-throughput

0.536

High

1270776

H2AJ
Histone H2A.J

1

2

High-throughput

0.536

High

1270789

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

6

High-throughput

0.536

High

1270797

PUF60
Poly(U)-binding-splicing factor PUF60

1

10

High-throughput

0.536

High

1144532

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

2

High-throughput

0.521

High

948546

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1016343

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

1023565

CYC
Cytochrome c

1

0

High-throughput

0.513

High

1142798

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.513

High

1270754

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1270775

TCAL7
Transcription elongation factor A protein-like 7

1

0

High-throughput

0.513

High

1270802

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.513

High

1270807

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

127119

APBB1
Amyloid beta precursor protein binding family B member 1

1

2

High-throughput

0.501

High

1179048

ZN181
Zinc finger protein 181

1

0

High-throughput

0.493

High

694365

CO8A1
Collagen alpha-1(VIII) chain

1

2

High-throughput

0.489

High

134782

SAP18
Histone deacetylase complex subunit SAP18

1

5

High-throughput

0.479

High

157538

CTRO
Citron Rho-interacting kinase

1

13

High-throughput

0.479

High

223143

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

247974

NUPR1
Nuclear protein 1

1

6

High-throughput

0.479

High

260113

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.479

High

285972

SF3B1
Splicing factor 3B subunit 1

1

5

High-throughput

0.479

High

319864

UFL1
E3 UFM1-protein ligase 1

1

4

High-throughput

0.479

High

325907

UBR5
E3 ubiquitin-protein ligase UBR5

1

10

High-throughput

0.479

High

331081

KI20A
Kinesin-like protein KIF20A

1

13

High-throughput

0.479

High

335868

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

3

High-throughput

0.479

High

342930

HERC2
E3 ubiquitin-protein ligase HERC2

1

10

High-throughput

0.479

High

355546

NSD2
Histone-lysine N-methyltransferase NSD2

1

8

Small-scale

0.479

High

385891

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

13

High-throughput

0.479

High

401038

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

406317

MYCN
N-myc proto-oncogene protein

1

11

High-throughput

0.479

High

412143

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

414087

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

461636

HS90A
Heat shock protein HSP 90-alpha

1

3

High-throughput

0.479

High

468530

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

520157

ANDR
Androgen receptor

1

19

High-throughput

0.479

High

537395

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

583320

FOLR1
Folate receptor alpha

1

1

High-throughput

0.479

High

588999

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

606871

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

654651

TCEA1
Transcription elongation factor A protein 1

1

2

High-throughput

0.479

High

695786

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

714218

PML
Protein PML

1

14

High-throughput

0.479

High

768501

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

822154

PSB10
Proteasome subunit beta type-10

1

1

High-throughput

0.479

High

837685

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.479

High

862249

YAP1
Transcriptional coactivator YAP1

1

18

High-throughput

0.479

High

879214

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

12

High-throughput

0.479

High

883270

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

904867

MECP2
Methyl-CpG-binding protein 2

1

12

High-throughput

0.479

High

959192

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

965048

WDR5
WD repeat-containing protein 5

1

12

High-throughput

0.479

High

970694

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

979881

H4
Histone H4

1

6

High-throughput

0.479

High

995660

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.479

High

1067457

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.479

High

1085580

FOXO1
Forkhead box protein O1

1

7

High-throughput

0.479

High

1088887

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1094577

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

7

High-throughput

0.479

High

1111060

SNW1
SNW domain-containing protein 1

1

6

High-throughput

0.479

High

1137086

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

14

High-throughput

0.479

High

1137809

TNIP1
TNFAIP3-interacting protein 1

1

16

High-throughput

0.479

High

1140469

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

1194172

LARP7
La-related protein 7

1

19

High-throughput

0.479

High

1215681

RC3H1
Roquin-1

1

4

High-throughput

0.479

High

1229541

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

1246854

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

1270742

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1270743

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

9

High-throughput

0.479

High

1270744

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1270745

ZCH18
Zinc finger CCCH domain-containing protein 18

1

7

High-throughput

0.479

High

1270748

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

1270749

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

1270751

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1270753

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1270758

TOPB1
DNA topoisomerase 2-binding protein 1

1

9

High-throughput

0.479

High

1270759

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

1270761

RBP56
TATA-binding protein-associated factor 2N

1

19

High-throughput

0.479

High

1270764

SPDLY
Protein Spindly

1

1

High-throughput

0.479

High

1270766

AURKB
Aurora kinase B

1

9

High-throughput

0.479

High

1270769

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

2

High-throughput

0.479

High

1270771

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.479

High

1270772

NECD
Necdin

1

6

High-throughput

0.479

High

1270780

IN80B
INO80 complex subunit B

1

2

High-throughput

0.479

High

1270782

ARP6
Actin-related protein 6

1

4

High-throughput

0.479

High

1270784

CHM4B
Charged multivesicular body protein 4b

1

8

High-throughput

0.479

High

1270787

ECT2
Protein ECT2

1

10

High-throughput

0.479

High

1270790

BRD7
Bromodomain-containing protein 7

1

16

High-throughput

0.479

High

1270791

ANLN
Anillin

1

3

High-throughput

0.479

High

1270792

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

1270796

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1270798

AGO2
Protein argonaute-2

1

9

High-throughput

0.479

High

1270799

AGO1
Protein argonaute-1

1

9

High-throughput

0.479

High

1270803

NUDC
Nuclear migration protein nudC

1

3

High-throughput

0.479

High

1270805

AAR2
Protein AAR2 homolog

1

4

High-throughput

0.479

High

1270808

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

1

Small-scale

0.479

High

187118

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.458

High

1270747

DYH10
Dynein axonemal heavy chain 10

1

0

High-throughput

0.458

High

430072

JUN
Transcription factor Jun

1

12

High-throughput

0.445

High

471872

RU2B
U2 small nuclear ribonucleoprotein B''

1

18

High-throughput

0.445

High

530004

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

765649

BMI1
Polycomb complex protein BMI-1

1

7

High-throughput

0.445

High

911623

NCBP2
Nuclear cap-binding protein subunit 2

1

17

High-throughput

0.445

High

973960

RUXF
Small nuclear ribonucleoprotein F

1

9

High-throughput

0.445

High

1060458

DPOE1
DNA polymerase epsilon catalytic subunit A

1

1

High-throughput

0.445

High

1130313

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

5

High-throughput

0.445

High

1270746

S2611
Sodium-independent sulfate anion transporter

1

2

High-throughput

0.445

High

1270750

SRFB1
Serum response factor-binding protein 1

1

1

High-throughput

0.445

High

1270778

TSSK1
Testis-specific serine/threonine-protein kinase 1

1

4

High-throughput

0.445

High

1270781

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1270794

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

7

High-throughput

0.445

High

239851

PCDH7
Protocadherin-7

1

1

High-throughput

0.437

High

272281

OBSL1
Obscurin-like protein 1

1

5

High-throughput

0.437

High

953524

RAC3
Ras-related C3 botulinum toxin substrate 3

1

1

High-throughput

0.437

High

1134965

CUL7
Cullin-7

1

8

High-throughput

0.437

High

1136245

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.437

High

1258051

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

2

Small-scale

0.437

High

1270757

YLAT2
Y+L amino acid transporter 2

1

1

High-throughput

0.437

High

1270765

RN125
E3 ubiquitin-protein ligase RNF125

1

12

Small-scale

0.437

High

1270768

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

1270779

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.437

High

1270783

TXNIP
Thioredoxin-interacting protein

1

2

Small-scale

0.437

High

1270785

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

1108363

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.426

High

1132520

NAA30
N-alpha-acetyltransferase 30

1

0

High-throughput

0.426

High

1270786

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

1

0

High-throughput

0.426

High

686628

ELAV4
ELAV-like protein 4

1

6

High-throughput

0.407

High

1270767

S41A3
Solute carrier family 41 member 3

1

2

High-throughput

0.407

High

1270788

GHC1
Mitochondrial glutamate carrier 1

1

4

High-throughput

0.407

High

61054

FUCM
Fucose mutarotase

1

0

High-throughput

0.279

Low

169190

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

488060

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

686686

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

1

0

High-throughput

0.279

Low

1092775

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

1093755

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

1187880

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.279

Low

1218106

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

1270756

JPH3
Junctophilin-3

1

0

High-throughput

0.279

Low

1270762

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1270763

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

1270793

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.279

Low

1270795

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

1270809

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

1270774

CCD77
Coiled-coil domain-containing protein 77

1

0

High-throughput

0.269

Low

1226454

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1270755

CAPSL
Calcyphosin-like protein

1

0

High-throughput

0.249

Low

1270804

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

High-throughput

0.249

Low

62546

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

230194

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.232

Low

1270752

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025