HitPredict

Interactor 1: ANKL2 (Q86XL3)
Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)
Gene: ANKLE2

Interactor 2: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32877691
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Ras
Common GO terms	GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 938 Hs			1 618
+	Hs
		581148 ANKL2_HUMAN (1-938): 0: 1602: 100.00		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Hs
		953543 ANKL2_HUMAN (1-938): 0: 1602: 100.00		RAC3_HUMAN (3-168): 9.64e-79: 249: 27.22
+	Hs
		955345 ANKL2_HUMAN (1-938): 0: 1602: 100.00		CDC42_HUMAN (3-172): 5.7e-77: 244: 25.54
+	Hs
		1144989 ANKL2_HUMAN (1-938): 0: 1602: 100.00		RAB35_HUMAN (5-168): 3.57e-76: 242: 24.70
+	Hs
		1015572 ANKL2_HUMAN (1-938): 0: 1602: 100.00		RHOG_HUMAN (3-170): 1.69e-74: 238: 27.47
+	Hs
		976385 ANKL2_HUMAN (1-938): 0: 1602: 100.00		RB11A_HUMAN (5-202): 4.27e-72: 232: 19.00
+	Hs
		962232 ANKL2_HUMAN (1-938): 0: 1602: 100.00		RHOA_HUMAN (6-168): 1.75e-11: 65.5: 28.25
+	Hs
		466339 ANKL2_HUMAN (1-938): 0: 1602: 100.00		RHOC_HUMAN (6-168): 3.88e-11: 64.3: 28.25
+	Hs
		126679 ANKL2_HUMAN (1-938): 0: 1602: 100.00		RHOD_HUMAN (3-167): 1.27e-10: 63.2: 28.89