Protein: ANKL2
Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)

Gene: ANKL2, ANKLE2
Organism: Homo sapiens
Interactions: 222
UniProt ID: Q86XL3

Gene Ontology (top 5):
GO:0004860 - protein kinase inhibitor activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0007084 - mitotic nuclear membrane reassembly
GO:0007417 - central nervous system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

717888

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

7

0

High-throughput

0.718

High

994286

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

4

1

High-throughput

0.704

High

977536

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

6

1

High-throughput

0.674

High

522111

BCL2
Apoptosis regulator Bcl-2

1

0

High-throughput

0.656

High

648827

KCNA5
Potassium voltage-gated channel subfamily A member 5

2

1

High-throughput

0.628

High

466339

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.618

High

581148

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.618

High

777716

VGFR3
Vascular endothelial growth factor receptor 3

1

3

High-throughput

0.618

High

901914

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.618

High

953543

RAC3
Ras-related C3 botulinum toxin substrate 3

1

5

High-throughput

0.618

High

955345

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.618

High

962232

RHOA
Transforming protein RhoA

1

6

High-throughput

0.618

High

1015572

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.618

High

1293948

MIRO2
Mitochondrial Rho GTPase 2

1

9

High-throughput

0.618

High

1293984

STAC3
SH3 and cysteine-rich domain-containing protein 3

3

2

High-throughput

0.609

High

1293991

STAC
SH3 and cysteine-rich domain-containing protein

3

2

High-throughput

0.609

High

1294004

GHITM
Growth hormone-inducible transmembrane protein

2

0

High-throughput

0.602

High

820681

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.586

High

837703

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.586

High

934821

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.586

High

1111594

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.586

High

1293945

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.586

High

1241463

EDC4
Enhancer of mRNA-decapping protein 4

2

0

High-throughput

0.585

High

1294028

ALK
ALK tyrosine kinase receptor

3

5

Small-scale

0.585

High

137507

BT3A1
Butyrophilin subfamily 3 member A1

1

0

High-throughput

0.578

High

158464

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.578

High

1293992

MPP8
M-phase phosphoprotein 8

1

0

High-throughput

0.578

High

1293990

SEC62
Translocation protein SEC62

2

0

High-throughput

0.559

High

126679

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.553

High

179618

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

5

High-throughput

0.553

High

630561

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.553

High

630866

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.553

High

631323

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.553

High

901368

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.553

High

910119

RND2
Rho-related GTP-binding protein RhoN

1

7

High-throughput

0.553

High

1144989

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.553

High

1151760

RHOH
Rho-related GTP-binding protein RhoH

1

6

High-throughput

0.553

High

184642

MK13
Mitogen-activated protein kinase 13

1

0

High-throughput

0.549

High

1180854

S4A8
Electroneutral sodium bicarbonate exchanger 1

1

0

High-throughput

0.546

High

484178

PGFRB
Platelet-derived growth factor receptor beta

1

2

High-throughput

0.536

High

1226700

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

High-throughput

0.536

High

1293971

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

1

High-throughput

0.536

High

1294014

I17RB
Interleukin-17 receptor B

1

1

High-throughput

0.536

High

464000

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

3

High-throughput

0.533

High

976385

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.517

High

1004115

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.517

High

49529

SHSA3
Protein shisa-3 homolog

1

0

High-throughput

0.513

High

216741

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

351788

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.513

High

784829

ACHA7
Neuronal acetylcholine receptor subunit alpha-7

1

0

High-throughput

0.513

High

843730

HD
Huntingtin

1

0

High-throughput

0.513

High

913532

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

952503

CTXN1
Cortexin-1

1

0

High-throughput

0.513

High

1126317

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1203512

S45A4
Solute carrier family 45 member 4

1

0

High-throughput

0.513

High

1293953

F241A
Uncharacterized protein FAM241A

1

0

High-throughput

0.513

High

1293965

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.513

High

1293974

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1293981

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

1293994

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

1293998

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1294009

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

1294011

CP26B
Cytochrome P450 26B1

1

0

High-throughput

0.513

High

553429

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

1

High-throughput

0.489

High

572939

INSRR
Insulin receptor-related protein

1

6

High-throughput

0.489

High

871477

LEPR
Leptin receptor

1

1

High-throughput

0.489

High

1178511

KI26B
Kinesin-like protein KIF26B

1

1

High-throughput

0.489

High

1252011

STAC2
SH3 and cysteine-rich domain-containing protein 2

1

2

High-throughput

0.489

High

1293960

O2T33
Olfactory receptor 2T33

1

3

High-throughput

0.489

High

1293961

OR2M7
Olfactory receptor 2M7

1

3

High-throughput

0.489

High

1293962

OR1M1
Olfactory receptor 1M1

1

3

High-throughput

0.489

High

1293963

OR5L1
Olfactory receptor 5L1

1

3

High-throughput

0.489

High

1293964

OR6T1
Olfactory receptor 6T1

1

4

High-throughput

0.489

High

1293979

I17RA
Interleukin-17 receptor A

1

1

High-throughput

0.489

High

1293980

NUD11
Diphosphoinositol polyphosphate phosphohydrolase 3-beta

1

2

High-throughput

0.489

High

1293993

OSMR
Oncostatin-M-specific receptor subunit beta

1

1

High-throughput

0.489

High

1293995

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

1

High-throughput

0.489

High

1294003

KLK15
Kallikrein-15

1

2

High-throughput

0.489

High

1294010

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.489

High

1294022

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

231598

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.481

High

48683

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

173979

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

412205

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

439771

INSR
Insulin receptor

1

6

High-throughput

0.479

High

540541

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

562188

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

604071

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

642958

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

1087173

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1228988

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

1245086

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1287364

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.479

High

1293956

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1293966

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1293972

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

1293982

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1293986

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

1293996

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1294001

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.479

High

1294015

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.479

High

1294026

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.479

High

1294027

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

210582

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.458

High

291418

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

327338

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

417550

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418246

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

548347

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.458

High

611210

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

654461

EST1
Liver carboxylesterase 1

1

0

High-throughput

0.458

High

698841

CALX
Calnexin

1

0

High-throughput

0.458

High

715656

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

831013

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

847589

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

880598

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

894875

EMD
Emerin

1

0

High-throughput

0.458

High

903990

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

951242

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1027064

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.458

High

1058503

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1125522

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1248988

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1252107

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1293947

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1293955

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1293957

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1293976

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1293985

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1293997

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1293999

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1294002

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1294008

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1294012

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1294013

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

1294017

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

1294018

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1294021

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1294023

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1294031

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.458

High

1294033

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

1294034

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

211145

CTR4
Cationic amino acid transporter 4

1

1

High-throughput

0.445

High

437724

HEPS
Serine protease hepsin

1

3

High-throughput

0.445

High

722515

CTR1
High affinity cationic amino acid transporter 1

1

1

High-throughput

0.445

High

991056

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

Small-scale

0.445

High

1293951

S39AB
Zinc transporter ZIP11

1

1

High-throughput

0.445

High

188926

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.437

High

189676

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

323469

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.437

High

710345

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.437

High

710724

EPHA8
Ephrin type-A receptor 8

1

3

High-throughput

0.437

High

1286817

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

1293950

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1293967

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1294019

RTEL1
Regulator of telomere elongation helicase 1

1

1

High-throughput

0.437

High

1294020

NUDT4
Diphosphoinositol polyphosphate phosphohydrolase 2

1

2

High-throughput

0.437

High

1294029

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.437

High

869618

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

High-throughput

0.426

High

1175873

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.426

High

1180285

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

1236208

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1294024

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.426

High

165

NUD4B
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B

1

2

High-throughput

0.407

High

94370

D6RA96
Regulator of telomere elongation helicase 1

1

1

High-throughput

0.407

High

1242846

S39A4
Zinc transporter ZIP4

1

1

High-throughput

0.407

High

1293958

ZNT7
Zinc transporter 7

1

1

High-throughput

0.407

High

219641

B2L11
Bcl-2-like protein 11

3

0

High-throughput

0.347

High

1293970

GLMN
Glomulin

3

0

High-throughput

0.345

High

665046

IL4RA
Interleukin-4 receptor subunit alpha

2

0

High-throughput

0.328

High

1156936

CNGA3
Cyclic nucleotide-gated channel alpha-3

2

0

High-throughput

0.328

High

1294035

VPP2
V-type proton ATPase 116 kDa subunit a 2

2

0

High-throughput

0.328

High

1065001

FGL1
Fibrinogen-like protein 1

2

0

High-throughput

0.318

High

74535

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

553003

PIP
Prolactin-inducible protein

1

0

High-throughput

0.279

Low

844262

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.279

Low

1044360

HSF2
Heat shock factor protein 2

1

0

High-throughput

0.279

Low

1204066

UROL1
Uromodulin-like 1

1

0

High-throughput

0.279

Low

1242338

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

1257783

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.279

Low

1293949

ABCA6
ATP-binding cassette sub-family A member 6

1

0

High-throughput

0.279

Low

1293954

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

1293973

T106A
Transmembrane protein 106A

1

0

High-throughput

0.279

Low

1293977

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.279

Low

1293987

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1293988

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1294000

DNAI2
Dynein axonemal intermediate chain 2

1

0

High-throughput

0.279

Low

1294006

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.279

Low

1294030

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.279

Low

1294032

FAN1
Fanconi-associated nuclease 1

1

0

High-throughput

0.279

Low

336123

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

0

High-throughput

0.265

Low

1293983

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.265

Low

226109

STX6
Syntaxin-6

1

0

High-throughput

0.249

Low

293957

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

474795

VIME
Vimentin

1

0

High-throughput

0.249

Low

580655

AMPN
Aminopeptidase N

1

0

High-throughput

0.249

Low

695864

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768577

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1134478

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

0

High-throughput

0.249

Low

1226156

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.249

Low

1238726

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

1254487

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1288475

LBN
Limbin

1

0

High-throughput

0.249

Low

1289087

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

0

Small-scale

0.249

Low

1293052

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1293603

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1293959

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

1293969

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

0

High-throughput

0.249

Low

1293975

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1293978

KTI12
Protein KTI12 homolog

1

0

Small-scale

0.249

Low

1293989

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1294005

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1294007

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1294016

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1294025

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

653420

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

896408

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.232

Low

1211926

S35F1
Solute carrier family 35 member F1

1

0

High-throughput

0.232

Low

1293946

S22A9
Organic anion transporter 7

1

0

High-throughput

0.232

Low

1293952

FXL16
F-box/LRR-repeat protein 16

1

0

High-throughput

0.232

Low

1293968

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025