Protein: ANKL2
Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)

Gene: ANKL2, ANKLE2
Organism: Homo sapiens
Interactions: 197
UniProt ID: Q86XL3

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0007084 - mitotic nuclear membrane reassembly
GO:0007417 - central nervous system development
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

672197

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

6

0

High-throughput

0.708

High

930911

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

4

1

High-throughput

0.704

High

915234

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

6

1

High-throughput

0.674

High

489435

BCL2
Apoptosis regulator Bcl-2

1

0

High-throughput

0.656

High

436387

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.618

High

545477

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.618

High

729307

VGFR3
Vascular endothelial growth factor receptor 3

1

3

High-throughput

0.618

High

845582

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.618

High

892466

RAC3
Ras-related C3 botulinum toxin substrate 3

1

5

High-throughput

0.618

High

894183

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.618

High

900653

RHOA
Transforming protein RhoA

1

6

High-throughput

0.618

High

951128

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.618

High

1204541

MIRO2
Mitochondrial Rho GTPase 2

1

9

High-throughput

0.618

High

1204573

STAC3
SH3 and cysteine-rich domain-containing protein 3

3

2

High-throughput

0.609

High

1204580

STAC
SH3 and cysteine-rich domain-containing protein

3

2

High-throughput

0.609

High

1204593

GHITM
Growth hormone-inducible transmembrane protein

2

0

High-throughput

0.602

High

785999

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.586

High

875086

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.586

High

130299

BT3A1
Butyrophilin subfamily 3 member A1

1

0

High-throughput

0.578

High

149883

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.578

High

1204581

MPP8
M-phase phosphoprotein 8

1

0

High-throughput

0.578

High

1204579

SEC62
Translocation protein SEC62

2

0

High-throughput

0.559

High

120519

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.553

High

169185

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

5

High-throughput

0.553

High

591611

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.553

High

591912

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.553

High

592352

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.553

High

845051

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.553

High

852542

RND2
Rho-related GTP-binding protein RhoN

1

7

High-throughput

0.553

High

1070277

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.553

High

1076644

RHOH
Rho-related GTP-binding protein RhoH

1

6

High-throughput

0.553

High

173897

MK13
Mitogen-activated protein kinase 13

1

0

High-throughput

0.549

High

452453

PGFRB
Platelet-derived growth factor receptor beta

1

2

High-throughput

0.536

High

1146349

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

High-throughput

0.536

High

1204560

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

1

High-throughput

0.536

High

1204603

I17RB
Interleukin-17 receptor B

1

1

High-throughput

0.536

High

434231

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

3

High-throughput

0.533

High

914185

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.517

High

940481

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.517

High

49211

SHSA3
Protein shisa-3 homolog

1

0

High-throughput

0.513

High

203985

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

328225

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.513

High

736147

ACHA7
Neuronal acetylcholine receptor subunit alpha-7

1

0

High-throughput

0.513

High

791728

HD
Huntingtin

1

0

High-throughput

0.513

High

855682

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

891468

CTXN1
Cortexin-1

1

0

High-throughput

0.513

High

1053779

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1124855

S45A4
Solute carrier family 45 member 4

1

0

High-throughput

0.513

High

1158971

EDC4
Enhancer of mRNA-decapping protein 4

1

0

High-throughput

0.513

High

1204544

F241A
Uncharacterized protein FAM241A

1

0

High-throughput

0.513

High

1204555

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.513

High

1204563

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1204570

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

1204583

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

1204587

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1204598

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

1204600

CP26B
Cytochrome P450 26B1

1

0

High-throughput

0.513

High

519412

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

1

High-throughput

0.489

High

537754

INSRR
Insulin receptor-related protein

1

5

High-throughput

0.489

High

817322

LEPR
Leptin receptor

1

1

High-throughput

0.489

High

1101424

KI26B
Kinesin-like protein KIF26B

1

1

High-throughput

0.489

High

1168468

STAC2
SH3 and cysteine-rich domain-containing protein 2

1

2

High-throughput

0.489

High

1204550

O2T33
Olfactory receptor 2T33

1

3

High-throughput

0.489

High

1204551

OR2M7
Olfactory receptor 2M7

1

3

High-throughput

0.489

High

1204552

OR1M1
Olfactory receptor 1M1

1

3

High-throughput

0.489

High

1204553

OR5L1
Olfactory receptor 5L1

1

3

High-throughput

0.489

High

1204554

OR6T1
Olfactory receptor 6T1

1

4

High-throughput

0.489

High

1204568

I17RA
Interleukin-17 receptor A

1

1

High-throughput

0.489

High

1204569

NUD11
Diphosphoinositol polyphosphate phosphohydrolase 3-beta

1

2

High-throughput

0.489

High

1204582

OSMR
Oncostatin-M-specific receptor subunit beta

1

1

High-throughput

0.489

High

1204592

KLK15
Kallikrein-15

1

2

High-throughput

0.489

High

1204599

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.489

High

1204611

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

217908

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.481

High

48408

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

163868

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

385115

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

411423

INSR
Insulin receptor

1

5

High-throughput

0.479

High

507103

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

527585

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

567146

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

1017692

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1148123

RNF43
E3 ubiquitin-protein ligase RNF43

1

2

High-throughput

0.479

High

1162081

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1198613

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.479

High

1204547

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1204556

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1204561

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

1204571

DNJC1
DnaJ homolog subfamily C member 1

1

3

High-throughput

0.479

High

1204575

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

1204585

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1204590

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.479

High

1204604

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

1204614

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.479

High

1204615

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

198274

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.458

High

273876

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

305524

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

390338

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

390997

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

514700

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.458

High

573780

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

654502

CALX
Calnexin

1

0

High-throughput

0.458

High

670096

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

779689

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

795184

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

825460

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

838954

EMD
Emerin

1

0

High-throughput

0.458

High

847538

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

890238

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

961713

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.458

High

990529

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1040155

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1053055

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1165728

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1168560

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1204540

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1204546

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1204548

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1204565

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1204574

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1204586

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1204588

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1204591

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1204597

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1204601

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1204602

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

1204606

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

1204607

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1204610

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1204612

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1204619

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.458

High

1204621

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

1204622

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

927840

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

Small-scale

0.445

High

177931

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.437

High

178637

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

301910

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.437

High

665493

EPHA8
Ephrin type-A receptor 8

1

2

High-throughput

0.437

High

1198083

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

1204543

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1204557

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1204608

RTEL1
Regulator of telomere elongation helicase 1

1

1

High-throughput

0.437

High

1204609

NUDT4
Diphosphoinositol polyphosphate phosphohydrolase 2

1

2

High-throughput

0.437

High

1204616

ALK
ALK tyrosine kinase receptor

1

5

High-throughput

0.437

High

1204617

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.437

High

1103052

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

165

NUD4B
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B

1

2

High-throughput

0.407

High

90023

D6RA96
Regulator of telomere elongation helicase 1

1

1

High-throughput

0.407

High

206756

B2L11
Bcl-2-like protein 11

3

0

High-throughput

0.347

High

608282

KCNA5
Potassium voltage-gated channel subfamily A member 5

2

0

High-throughput

0.328

High

622743

IL4RA
Interleukin-4 receptor subunit alpha

2

0

High-throughput

0.328

High

1081477

CNGA3
Cyclic nucleotide-gated channel alpha-3

2

0

High-throughput

0.328

High

1204559

GLMN
Glomulin

2

0

High-throughput

0.328

High

1204623

VPP2
V-type proton ATPase 116 kDa subunit a 2

2

0

High-throughput

0.328

High

996491

FGL1
Fibrinogen-like protein 1

2

0

High-throughput

0.318

High

71169

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

519028

PIP
Prolactin-inducible protein

1

0

High-throughput

0.279

Low

792239

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.279

Low

977903

HSF2
Heat shock factor protein 2

1

0

High-throughput

0.279

Low

1125381

UROL1
Uromodulin-like 1

1

0

High-throughput

0.279

Low

1159676

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

1173732

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.279

Low

1204542

ABCA6
ATP-binding cassette sub-family A member 6

1

0

High-throughput

0.279

Low

1204545

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

1204562

T106A
Transmembrane protein 106A

1

0

High-throughput

0.279

Low

1204566

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.279

Low

1204576

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1204577

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1204584

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

0

High-throughput

0.279

Low

1204589

DNAI2
Dynein axonemal intermediate chain 2

1

0

High-throughput

0.279

Low

1204595

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.279

Low

1204618

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.279

Low

1204620

FAN1
Fanconi-associated nuclease 1

1

0

High-throughput

0.279

Low

313557

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

0

High-throughput

0.265

Low

1204572

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.265

Low

212910

STX6
Syntaxin-6

1

0

High-throughput

0.249

Low

443629

VIME
Vimentin

1

0

High-throughput

0.249

Low

544995

AMPN
Aminopeptidase N

1

0

High-throughput

0.249

Low

651608

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720847

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1145818

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.249

Low

1156622

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

1170660

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1199587

LBN
Limbin

1

0

High-throughput

0.249

Low

1200157

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

0

Small-scale

0.249

Low

1203752

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1204273

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1204549

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

1204558

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

0

High-throughput

0.249

Low

1204564

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1204567

KTI12
Protein KTI12 homolog

1

0

Small-scale

0.249

Low

1204578

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1204594

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1204596

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1204605

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1204613

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024