HitPredict

Interactor 1: SPF45 (Q96I25)
Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)
Gene: RBM17

Interactor 2: SRPK3 (Q9UPE1)
SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)
Gene: SRPK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 401 Hs			1 567
+	Hs
		625557 SPF45_HUMAN (1-401): 4.66e-158: 452: 100.00		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		942871 SPF45_HUMAN (1-401): 4.66e-158: 452: 100.00		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		1054671 RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76		SRPK3_HUMAN (27-567): 5.16e-140: 418: 100.00
+	Hs
		641982 U2AF2_HUMAN (244-397): 2.42e-36: 140: 23.93		SRPK3_HUMAN (27-567): 5.16e-140: 418: 100.00
+	Sp
		143387 RSD1_SCHPO (130-392): 3.55e-53: 188: 19.63		DSK1_SCHPO (3-565): 8.43e-109: 338: 35.27
+	At
		789607 DR111_ARATH (37-398): 1.88e-81: 256: 31.33		MPK4_ARATH (82-401): 4.37e-78: 252: 15.24
+	Hs
		942653 RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		833880 RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		1054522 RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	At
		789605 DR111_ARATH (37-398): 1.88e-81: 256: 31.33		MPK1_ARATH (57-258): 5.52e-49: 175: 19.62
+	Hs
		625633 PUF60_HUMAN (131-398): 8.05e-33: 131: 16.67		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		641712 U2AF2_HUMAN (244-397): 2.42e-36: 140: 23.93		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		641666 U2AF2_HUMAN (244-397): 2.42e-36: 140: 23.93		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		641901 U2AF2_HUMAN (244-397): 2.42e-36: 140: 23.93		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Zm
		43418 A0A1D6PK18_MAIZE (88-393): 2.71e-45: 166: 14.06		B6TES5_MAIZE (75-258): 1.12e-50: 180: 20.75
+	Hs
		834041 RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		833736 RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76		CLK1_HUMAN (405-566): 8.71e-11: 66.2: 26.01
+	Dm
		834204 Q9VM49_DROME (81-394): 1.42e-65: 220: 14.07		DOA_DROME (396-566): 7.94e-12: 70.1: 25.41
+	Sp
		143391 RSD1_SCHPO (130-392): 3.55e-53: 188: 19.63		LKH1_SCHPO (404-565): 1.99e-12: 72: 27.81
+	Hs
		641667 U2AF2_HUMAN (244-397): 2.42e-36: 140: 23.93		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97