HitPredict

Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Interactor 2: PACN1 (Q9BY11)
Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1)
Gene: PACSIN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	26613292, 28235806
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology, far western blotting, pull down, unspecified method
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 903 Hs			1 444
+	Hs
		1078893 ITCH_HUMAN (1-903): 0: 926: 100.00		ITSN1_HUMAN (367-442): 5.46e-13: 73.6: 31.58
+	Hs
		125483 WWP2_HUMAN (1-903): 0: 816: 54.08		CIP4_HUMAN (19-391): 3.5e-42: 159: 15.12
+	Dm
		1363736 NEDD4_DROME (3-901): 0: 720: 29.95		Q9VDI1_DROME (16-442): 4.51e-70: 231: 38.46
+	Hs
		808311 NEDD4_HUMAN (90-900): 0: 673: 34.16		BI2L1_HUMAN (123-444): 2.84e-36: 141: 13.94
+	Hs
		802865 HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88		CRKL_HUMAN (366-444): 7.4e-12: 68: 32.91
+	Hs
		1075816 SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71		CIP4_HUMAN (19-391): 3.5e-42: 159: 15.12
+	Hs
		1350495 HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34		BI2L1_HUMAN (123-444): 2.84e-36: 141: 13.94