HitPredict

Interactor 1: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	29180510, 37633270, 19916563
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~zf-RING_6
Common GO terms	GO:0005634 - nucleus GO:0046982 - protein heterodimerization activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 129 Hs			1 777
+	Hs
		391861 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		555617 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		470446 H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06		ANKH1_HUMAN (114-664): 2.01e-66: 242: 14.16
+	Hs
		391781 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		ANKH1_HUMAN (114-664): 2.01e-66: 242: 14.16
+	Hs
		555536 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		ANKH1_HUMAN (114-664): 2.01e-66: 242: 14.16
+	Hs
		555510 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		BCOR_HUMAN (152-543): 1.16e-44: 176: 23.93
+	Hs
		1087083 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1293188 H2AJ_HUMAN (1-129): 1.81e-66: 198: 96.90		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1151369 H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		470504 H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		391842 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		555597 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1087014 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		TNI3K_HUMAN (452-551): 1.71e-15: 82.9: 21.64
+	Hs
		1237344 H2A1H_HUMAN (1-127): 1.77e-65: 196: 96.06		ANR31_HUMAN (423-543): 1.48e-11: 70.5: 38.02