HitPredict

Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Interactor 2: TMM51 (Q9NW97)
Transmembrane protein 51
Gene: TMEM51

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	26186194, 28514442, 33961781, 37219487
Identification Methods	affinity chromatography technology, unspecified method, phage display, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 903 Hs			1 253
+	Hs
		1327923 WWP1_HUMAN (1-903): 0: 832: 57.54		TMM51_HUMAN (1-253): 4.38e-174: 481: 100.00
+	Hs
		125753 WWP2_HUMAN (1-903): 0: 816: 54.08		TMM51_HUMAN (1-253): 4.38e-174: 481: 100.00
+	Hs
		1299648 NED4L_HUMAN (5-900): 0: 762: 32.14		TMM51_HUMAN (1-253): 4.38e-174: 481: 100.00
+	Hs
		808292 NEDD4_HUMAN (90-900): 0: 673: 34.16		TMM51_HUMAN (1-253): 4.38e-174: 481: 100.00
+	Hs
		1347135 HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34		TMM51_HUMAN (1-253): 4.38e-174: 481: 100.00