Protein: PAI1
Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)

Gene: PAI1, SERPINE1
Organism: Homo sapiens
Interactions: 46
UniProt ID: P05121

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341479

UROK
Urokinase-type plasminogen activator

4

20

Small-scale

0.896

High

341526

TPA
Tissue-type plasminogen activator

2

20

Small-scale

0.778

High

372974

VTNC
Vitronectin

2

2

Small-scale

0.778

High

341125

THRB
Prothrombin

1

20

Small-scale

0.647

High

341339

PLMN
Plasminogen

1

20

Small-scale

0.647

High

213446

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

3

4

High-throughput

0.616

High

397109

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

3

5

High-throughput

0.616

High

363421

A1AG1
Alpha-1-acid glycoprotein 1

2

2

Small-scale

0.606

High

397114

UBQL2
Ubiquilin-2

2

7

High-throughput

0.606

High

397088

CFTR
Cystic fibrosis transmembrane conductance regulator

2

8

High-throughput

0.601

High

397104

SMAD4
Mothers against decapentaplegic homolog 4

3

3

Small-scale

0.593

High

397103

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

0

Small-scale

0.586

High

397101

SMAD3
Mothers against decapentaplegic homolog 3

2

3

Small-scale

0.584

High

397085

PAI1
Plasminogen activator inhibitor 1

1

5

Small-scale

0.575

High

397115

UBQL1
Ubiquilin-1

1

7

High-throughput

0.573

High

211781

TLX3
T-cell leukemia homeobox protein 3

2

1

High-throughput

0.553

High

397100

PITX1
Pituitary homeobox 1

2

3

High-throughput

0.553

High

397089

ENPL
Endoplasmin

1

4

High-throughput

0.536

High

397086

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

397087

PPBI
Intestinal-type alkaline phosphatase

1

0

High-throughput

0.513

High

397105

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.513

High

397112

UBQL4
Ubiquilin-4

1

8

High-throughput

0.494

High

397094

ERP29
Endoplasmic reticulum resident protein 29

1

3

High-throughput

0.489

High

397096

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

1

High-throughput

0.489

High

167324

SMAD7
Mothers against decapentaplegic homolog 7

1

3

Small-scale

0.479

High

204923

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

373507

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

397090

PSB1
Proteasome subunit beta type-1

1

1

Small-scale

0.479

High

397092

PSA3
Proteasome subunit alpha type-3

1

2

Small-scale

0.479

High

397102

VIGLN
Vigilin

1

3

High-throughput

0.479

High

397113

FBLN5
Fibulin-5

1

2

Small-scale

0.479

High

397091

IBP5
Insulin-like growth factor-binding protein 5

1

0

Small-scale

0.458

High

397093

LYOX
Protein-lysine 6-oxidase

1

0

Small-scale

0.458

High

397095

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

397098

MFAP2
Microfibrillar-associated protein 2

1

0

Small-scale

0.458

High

397106

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

359565

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.439

High

345675

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

397097

SOX2
Transcription factor SOX-2

1

11

High-throughput

0.437

High

397099

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.437

High

397107

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

397111

ANLN
Anillin

1

2

High-throughput

0.437

High

397108

DHB11
Estradiol 17-beta-dehydrogenase 11

2

0

High-throughput

0.316

High

397110

TM237
Transmembrane protein 237

2

0

High-throughput

0.316

High

320947

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024