Protein: SEM4C
Semaphorin-4C

Gene: SEM4C, SEMA4C
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q9C0C4

Gene Ontology (top 5):
GO:0001755 - neural crest cell migration
GO:0001843 - neural tube closure
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007411 - axon guidance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

175421

PLXB2
Plexin-B2

1

20

High-throughput

0.691

High

1420843

SEM4A
Semaphorin-4A

1

12

High-throughput

0.691

High

1146151

K1H1
Keratin, type I cuticular Ha1

3

3

High-throughput

0.675

High

553440

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

0

High-throughput

0.656

High

374181

RASN
GTPase NRas

3

10

High-throughput

0.640

High

375921

RASK
GTPase KRas

3

10

High-throughput

0.640

High

167646

GIPC1
PDZ domain-containing protein GIPC1

2

5

High-throughput

0.611

High

300489

KRT34
Keratin, type I cuticular Ha4

2

3

High-throughput

0.606

High

749391

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

0

High-throughput

0.602

High

1253168

NBEL2
Neurobeachin-like protein 2

2

1

High-throughput

0.601

High

1420857

FBX2
F-box only protein 2

2

9

High-throughput

0.601

High

630961

RAB4A
Ras-related protein Rab-4A

2

2

High-throughput

0.584

High

976545

RB11A
Ras-related protein Rab-11A

2

2

High-throughput

0.584

High

1277394

NT2NA
Notch homolog 2 N-terminal-like protein A

2

10

High-throughput

0.578

High

139311

UPK2
Uroplakin-2

2

0

High-throughput

0.576

High

260949

RAMP3
Receptor activity-modifying protein 3

2

0

High-throughput

0.576

High

1006101

DLG4
Disks large homolog 4

1

7

Small-scale

0.573

High

396896

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

70469

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

269369

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.553

High

476386

K1C16
Keratin, type I cytoskeletal 16

2

3

High-throughput

0.553

High

1277626

K1C27
Keratin, type I cytoskeletal 27

2

2

High-throughput

0.553

High

1330078

USBP1
Harmonin-binding protein USHBP1

2

1

High-throughput

0.553

High

1420863

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.553

High

125905

ARVC
Splicing regulator ARVCF

1

1

High-throughput

0.536

High

380481

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

12

High-throughput

0.536

High

480893

LEG1
Galectin-1

1

1

High-throughput

0.536

High

548112

PSPC
Surfactant protein C

1

3

High-throughput

0.536

High

637950

NF1
Neurofibromin

1

1

High-throughput

0.536

High

818837

TYRP2
L-dopachrome tautomerase

1

1

High-throughput

0.536

High

827918

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.536

High

839358

MTOR
Serine/threonine-protein kinase mTOR

1

10

High-throughput

0.536

High

898135

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

2

High-throughput

0.536

High

1047244

ATP7A
Copper-transporting ATPase 1

1

1

High-throughput

0.536

High

1128950

I13R2
Interleukin-13 receptor subunit alpha-2

1

6

High-throughput

0.536

High

1187221

CC50B
Cell cycle control protein 50B

1

2

High-throughput

0.536

High

1247711

SARM1
NAD(+) hydrolase SARM1

1

1

High-throughput

0.536

High

1335847

DYHC2
Cytoplasmic dynein 2 heavy chain 1

1

8

High-throughput

0.536

High

1368751

SYMPK
Symplekin

1

1

High-throughput

0.536

High

1420854

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.536

High

1420866

PCDB3
Protocadherin beta-3

1

3

High-throughput

0.536

High

1230247

K1C40
Keratin, type I cytoskeletal 40

1

3

High-throughput

0.523

High

301682

WFS1
Wolframin

1

1

High-throughput

0.515

High

890885

TSC2
Tuberin

1

0

High-throughput

0.513

High

1119884

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.513

High

1338832

FLCN
Folliculin

1

0

High-throughput

0.513

High

1347246

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.513

High

1349687

CIP2A
Protein CIP2A

1

0

High-throughput

0.513

High

1420861

EXOC7
Exocyst complex component 7

1

0

High-throughput

0.513

High

255202

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.500

High

1119297

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.500

High

1419214

TRI54
Tripartite motif-containing protein 54

1

4

High-throughput

0.494

High

173749

BTAF1
TATA-binding protein-associated factor 172

1

5

High-throughput

0.489

High

251805

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

1

High-throughput

0.489

High

273230

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

4

High-throughput

0.489

High

699090

CALX
Calnexin

1

3

High-throughput

0.489

High

873751

GSH0
Glutamate--cysteine ligase regulatory subunit

1

2

High-throughput

0.489

High

1109505

ATR
Serine/threonine-protein kinase ATR

1

11

High-throughput

0.489

High

1140814

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.489

High

1226421

TBC9B
TBC1 domain family member 9B

1

1

High-throughput

0.489

High

1244964

FIGL1
Fidgetin-like protein 1

1

1

High-throughput

0.489

High

1325388

STAG2
Cohesin subunit SA-2

1

2

High-throughput

0.489

High

1356705

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

1

High-throughput

0.489

High

1420536

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

4

High-throughput

0.489

High

1420850

HELLS
Lymphoid-specific helicase

1

4

High-throughput

0.489

High

1420862

PLAP
Phospholipase A-2-activating protein

1

2

High-throughput

0.489

High

1420867

TNPO3
Transportin-3

1

1

High-throughput

0.489

High

1420871

NEMO
NF-kappa-B essential modulator

1

2

High-throughput

0.489

High

1152418

DLG2
Disks large homolog 2

1

7

Small-scale

0.481

High

1368717

DLG3
Disks large homolog 3

1

7

Small-scale

0.481

High

189817

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

218742

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

341139

DIRA3
GTP-binding protein Di-Ras3

1

2

High-throughput

0.479

High

374909

RASH
GTPase HRas

1

9

High-throughput

0.479

High

463750

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.479

High

604190

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

630625

RAB3B
Ras-related protein Rab-3B

1

2

High-throughput

0.479

High

631457

RAB5A
Ras-related protein Rab-5A

1

3

High-throughput

0.479

High

710472

EPHA2
Ephrin type-A receptor 2

1

6

High-throughput

0.479

High

901023

RAB5C
Ras-related protein Rab-5C

1

3

High-throughput

0.479

High

901547

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.479

High

902052

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.479

High

931442

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

2

High-throughput

0.479

High

945091

RAB25
Ras-related protein Rab-25

1

2

High-throughput

0.479

High

978282

RHOB
Rho-related GTP-binding protein RhoB

1

5

High-throughput

0.479

High

1087270

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

1145100

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.479

High

1227412

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

1322975

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.479

High

1360202

5HT3C
5-hydroxytryptamine receptor 3C

1

3

High-throughput

0.479

High

1384761

ARL8A
ADP-ribosylation factor-like protein 8A

1

1

High-throughput

0.479

High

1420852

CC50A
Cell cycle control protein 50A

1

2

High-throughput

0.479

High

1420859

ALK
ALK tyrosine kinase receptor

1

5

High-throughput

0.479

High

1420860

AT1B4
Protein ATP1B4

1

2

High-throughput

0.479

High

1353627

GIPC2
PDZ domain-containing protein GIPC2

1

5

High-throughput

0.470

High

231759

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.470

High

517108

NT2NC
Notch homolog 2 N-terminal-like protein C

1

10

High-throughput

0.470

High

378181

TNFA
Tumor necrosis factor

1

0

High-throughput

0.458

High

459745

PROF1
Profilin-1

1

0

High-throughput

0.458

High

975227

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1159829

OCLN
Occludin

1

0

High-throughput

0.458

High

1233467

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1249194

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1351230

MCLN3
Mucolipin-3

1

0

High-throughput

0.458

High

1396800

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1420858

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.458

High

530347

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

733717

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

1

2

High-throughput

0.445

High

839503

PI4KA
Phosphatidylinositol 4-kinase alpha

1

8

High-throughput

0.445

High

1197881

S39AC
Zinc transporter ZIP12

1

4

High-throughput

0.445

High

1242921

S39A4
Zinc transporter ZIP4

1

4

High-throughput

0.445

High

627

NBPFJ
NBPF family member NBPF19

1

4

High-throughput

0.439

High

1293138

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1334546

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.437

High

1367209

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

1381956

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1404187

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

1420848

FBX6
F-box only protein 6

1

9

High-throughput

0.437

High

876441

EAA4
Excitatory amino acid transporter 4

1

0

High-throughput

0.426

High

1273800

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.426

High

1420856

NCDN
Neurochondrin

1

0

High-throughput

0.426

High

1420864

TMM98
Transmembrane protein 98

1

0

High-throughput

0.426

High

170948

CLGN
Calmegin

1

3

High-throughput

0.407

High

1327594

WDTC1
WD and tetratricopeptide repeats protein 1

1

2

High-throughput

0.407

High

1363439

S39A7
Zinc transporter SLC39A7

1

4

High-throughput

0.407

High

1420847

AT131
Endoplasmic reticulum transmembrane helix translocase

1

1

High-throughput

0.407

High

1336465

PNMA1
Paraneoplastic antigen Ma1

3

0

High-throughput

0.352

High

1420846

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

1420840

BTBD1
BTB/POZ domain-containing protein 1

2

0

High-throughput

0.313

High

1420868

SNX5
Sorting nexin-5

2

0

High-throughput

0.313

High

1399845

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.299

High

137271

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.279

Low

164637

TNPO2
Transportin-2

1

0

High-throughput

0.279

Low

177596

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.279

Low

177941

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

0

High-throughput

0.279

Low

334095

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.279

Low

337194

APOM
Apolipoprotein M

1

0

High-throughput

0.279

Low

573238

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.279

Low

675667

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.279

Low

828443

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.279

Low

841248

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.279

Low

914118

HXK2
Hexokinase-2

1

0

High-throughput

0.279

Low

1121145

UBE4A
Ubiquitin conjugation factor E4 A

1

0

High-throughput

0.279

Low

1131893

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.279

Low

1212166

DPS1
All trans-polyprenyl-diphosphate synthase PDSS1

1

0

High-throughput

0.279

Low

1239823

MZT2B
Mitotic-spindle organizing protein 2B

1

0

High-throughput

0.279

Low

1278630

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1279228

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.279

Low

1294723

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.279

Low

1329564

ZFN2A
AN1-type zinc finger protein 2A

1

0

High-throughput

0.279

Low

1336526

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

1381709

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.279

Low

1383779

TTC28
Tetratricopeptide repeat protein 28

1

0

High-throughput

0.279

Low

1386780

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.279

Low

1395054

ELMO2
Engulfment and cell motility protein 2

1

0

High-throughput

0.279

Low

1414376

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.279

Low

1420839

XPO4
Exportin-4

1

0

High-throughput

0.279

Low

1420841

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

1420845

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.279

Low

1420849

F1142
Protein FAM114A2

1

0

High-throughput

0.279

Low

1420855

KLH42
Kelch-like protein 42

1

0

High-throughput

0.279

Low

1420865

NUB1
NEDD8 ultimate buster 1

1

0

High-throughput

0.279

Low

1420869

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

0

High-throughput

0.279

Low

1420870

TX264
Testis-expressed protein 264

1

0

High-throughput

0.279

Low

1186800

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

951405

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.249

Low

1197701

MIDN
Midnolin

1

0

High-throughput

0.249

Low

1420842

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1420844

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1420851

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1420853

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1389581

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025