HitPredict

Interactor 1: WASF2 (Q8BH43)
Actin-binding protein WASF2 (Protein WAVE-2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2)
Gene: WASF2

Interactor 2: BRK1 (Q91VR8)
Protein BRICK1 (BRK1)
Gene: BRK1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton GO:0010592 - positive regulation of lamellipodium assembly GO:0016601 - Rac protein signal transduction GO:0030027 - lamellipodium GO:0030036 - actin cytoskeleton organization and 2 others more... GO:0031209 - SCAR complex GO:0048870 - cell motility
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 497 Mm			1 75
+	Hs
		1357241 WASF2_HUMAN (1-497): 3.2e-81: 262: 85.60		BRK1_HUMAN (1-75): 2.44e-36: 118: 98.67
+	Hs
		1357231 WASF3_HUMAN (1-497): 2.57e-73: 242: 46.72		BRK1_HUMAN (1-75): 2.44e-36: 118: 98.67
+	Dm
		120194 M9PCP4_DROME (1-384): 1.16e-62: 217: 29.98		Q8MLQ0_DROME (2-75): 8.67e-36: 117: 72.97
+	Hs
		1357188 WASF1_HUMAN (1-495): 1.06e-62: 215: 41.76		BRK1_HUMAN (1-75): 2.44e-36: 118: 98.67
+	Bt
		72267 WASF1_BOVIN (1-495): 3.31e-62: 214: 41.76		A8YXX8_BOVIN (1-75): 2.47e-36: 118: 97.33
+	Dm
		99167 F2FB81_DROME (1-384): 5.02e-61: 213: 27.42		Q8MLQ0_DROME (2-75): 8.67e-36: 117: 72.97
+	At
		1231032 SCAR1_ARATH (1-259): 1.84e-64: 225: 18.15		BRK1_ARATH (12-69): 8.95e-24: 87: 43.10
+	At
		1376670 SCAR3_ARATH (1-162): 1.72e-58: 210: 24.55		BRK1_ARATH (12-69): 8.95e-24: 87: 43.10
+	At
		1220926 SCAR2_ARATH (1-221): 1.49e-53: 196: 21.55		BRK1_ARATH (12-69): 8.95e-24: 87: 43.10
+	Dd
		1200683 SCAR_DICDI (25-477): 1.09e-33: 134: 24.62		BRK1_DICDI (9-66): 3.46e-19: 75.1: 48.28