HitPredict

Interactor 1: NSD1 (Q96L73)
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)
Gene: NSD1

Interactor 2: ZN692 (Q9BU19)
Zinc finger protein 692 (AICAR responsive element binding protein)
Gene: ZNF692

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2696 Hs			1 519
+	Hs
		1286803 NSD1_HUMAN (1-2696): 0: 3408: 100.00		ZN653_HUMAN (326-472): 5.76e-38: 149: 48.30
+	Hs
		331879 NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63		ZN692_HUMAN (1-519): 8.43e-171: 494: 100.00
+	Hs
		203785 SUV91_HUMAN (1705-2081): 6.86e-87: 293: 21.86		ZN436_HUMAN (91-441): 4.78e-100: 311: 16.52
+	Hs
		599072 SETD2_HUMAN (1790-2119): 9.55e-63: 241: 27.98		ZNF10_HUMAN (219-518): 3.38e-91: 291: 20.07
+	Hs
		161833 EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80		ZN263_HUMAN (227-441): 4.92e-50: 184: 21.76
+	Hs
		1080129 EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80		ZN397_HUMAN (386-518): 1.27e-43: 164: 27.74
+	Hs
		1067381 EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80		OZF_HUMAN (348-467): 2.48e-11: 66.6: 31.97