Protein: TCAM1
TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)

Gene: TCAM1, TICAM1
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q8IUC6

Gene Ontology (top 5):
GO:0002224 - toll-like receptor signaling pathway
GO:0002281 - macrophage activation involved in immune response
GO:0002735 - positive regulation of myeloid dendritic cell cytokine production
GO:0005739 - mitochondrion
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1307134

TCAM1
TIR domain-containing adapter molecule 1

5

3

Small-scale

0.908

High

1307152

TBK1
Serine/threonine-protein kinase TBK1

14

3

Small-scale

0.759

High

1307155

TRAF6
TNF receptor-associated factor 6

9

12

Small-scale

0.756

High

1109620

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

9

5

Small-scale

0.747

High

1094925

TRAF3
TNF receptor-associated factor 3

8

10

Small-scale

0.741

High

191224

TLR3
Toll-like receptor 3

7

8

Small-scale

0.739

High

1090768

TRAF2
TNF receptor-associated factor 2

4

13

Small-scale

0.703

High

126320

TLR4
Toll-like receptor 4

4

8

Small-scale

0.683

High

1294140

TCAM2
TIR domain-containing adapter molecule 2

4

3

Small-scale

0.683

High

1129158

IRF3
Interferon regulatory factor 3

4

2

Small-scale

0.676

High

1093868

TRAF1
TNF receptor-associated factor 1

3

9

Small-scale

0.674

High

1132385

CASP8
Caspase-8

3

1

Small-scale

0.640

High

1293367

CARM1
Histone-arginine methyltransferase CARM1

3

0

High-throughput

0.634

High

1307156

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

4

Small-scale

0.618

High

1307139

TANK
TRAF family member-associated NF-kappa-B activator

2

1

Small-scale

0.611

High

1247697

SARM1
NAD(+) hydrolase SARM1

2

1

Small-scale

0.606

High

1307154

TMED7
Transmembrane emp24 domain-containing protein 7

3

2

Small-scale

0.581

High

132146

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

Small-scale

0.561

High

1307146

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

3

Small-scale

0.561

High

1307149

AZI2
5-azacytidine-induced protein 2

2

0

Small-scale

0.559

High

1307153

UBQL1
Ubiquilin-1

1

0

Small-scale

0.554

High

1307138

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

1

High-throughput

0.536

High

1307147

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

1

High-throughput

0.536

High

639263

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

Small-scale

0.515

High

1307144

TRI56
E3 ubiquitin-protein ligase TRIM56

1

3

Small-scale

0.515

High

1307145

TRAF4
TNF receptor-associated factor 4

1

11

Small-scale

0.515

High

187374

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

451622

GPX1
Glutathione peroxidase 1

1

0

High-throughput

0.513

High

1307142

CDCA5
Sororin

1

0

High-throughput

0.513

High

1278024

MAVS
Mitochondrial antiviral-signaling protein

1

0

Small-scale

0.493

High

1307136

PIAS4
E3 SUMO-protein ligase PIAS4

1

1

Small-scale

0.488

High

1146245

ZMY11
Zinc finger MYND domain-containing protein 11

1

0

Small-scale

0.484

High

136707

TRAF5
TNF receptor-associated factor 5

1

13

Small-scale

0.479

High

167928

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

3

Small-scale

0.479

High

193028

CFLAR
CASP8 and FADD-like apoptosis regulator

1

1

Small-scale

0.479

High

214447

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

4

Small-scale

0.479

High

252281

TLR5
Toll-like receptor 5

1

8

Small-scale

0.479

High

252357

TLR2
Toll-like receptor 2

1

8

Small-scale

0.479

High

849203

KSYK
Tyrosine-protein kinase SYK

1

3

Small-scale

0.479

High

1097945

CBLB
E3 ubiquitin-protein ligase CBL-B

1

1

Small-scale

0.479

High

1122523

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

Small-scale

0.479

High

1307140

IRF7
Interferon regulatory factor 7

1

2

Small-scale

0.479

High

1307151

RN216
E3 ubiquitin-protein ligase RNF216

1

1

Small-scale

0.479

High

142688

TRI38
E3 ubiquitin-protein ligase TRIM38

1

0

Small-scale

0.458

High

173029

XPO1
Exportin-1

1

0

High-throughput

0.458

High

322963

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

Small-scale

0.458

High

584030

FOSL1
Fos-related antigen 1

1

0

Small-scale

0.458

High

839043

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

1277995

R144B
E3 ubiquitin-protein ligase RNF144B

1

0

Small-scale

0.458

High

1307137

ABCF1
ATP-binding cassette sub-family F member 1

1

0

Small-scale

0.458

High

1307141

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.458

High

1307148

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

0

Small-scale

0.458

High

269458

KI21B
Kinesin-like protein KIF21B

1

0

High-throughput

0.279

Low

1307135

DI3L2
DIS3-like exonuclease 2

1

0

High-throughput

0.279

Low

1307150

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

0

High-throughput

0.279

Low

1062037

SRSF4
Serine/arginine-rich splicing factor 4

1

0

High-throughput

0.251

Low

1307143

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025