Protein: PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6)

Gene: PRGC1, PPARGC1A
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q9UBK2

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001659 - temperature homeostasis
GO:0001678 - intracellular glucose homeostasis
GO:0002021 - response to dietary excess
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740612

PPARG
Peroxisome proliferator-activated receptor gamma

20

20

Small-scale

0.765

High

510041

ERR1
Steroid hormone receptor ERR1

9

20

Small-scale

0.756

High

782680

HNF4A
Hepatocyte nuclear factor 4-alpha

7

19

Small-scale

0.750

High

914678

ERR3
Estrogen-related receptor gamma

6

20

Small-scale

0.732

High

265882

NR1I2
Nuclear receptor subfamily 1 group I member 2

4

20

Small-scale

0.698

High

960256

CDK6
Cyclin-dependent kinase 6

1

0

Small-scale

0.697

High

682051

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.647

High

130337

NR5A2
Nuclear receptor subfamily 5 group A member 2

3

18

Small-scale

0.640

High

370621

ESR1
Estrogen receptor

3

20

Small-scale

0.637

High

587203

RXRA
Retinoic acid receptor RXR-alpha

2

20

Small-scale

0.628

High

871494

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

Small-scale

0.618

High

967487

EWS
RNA-binding protein EWS

1

1

Small-scale

0.618

High

993858

SRSF4
Serine/arginine-rich splicing factor 4

1

2

Small-scale

0.618

High

1025231

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

Small-scale

0.618

High

1028858

SRSF5
Serine/arginine-rich splicing factor 5

1

2

Small-scale

0.618

High

1029144

SRSF6
Serine/arginine-rich splicing factor 6

1

2

Small-scale

0.618

High

836054

GSK3B
Glycogen synthase kinase-3 beta

1

0

Small-scale

0.614

High

500377

RARB
Retinoic acid receptor beta

2

20

High-throughput

0.606

High

975478

PPARD
Peroxisome proliferator-activated receptor delta

2

20

Small-scale

0.602

High

992454

PPARA
Peroxisome proliferator-activated receptor alpha

2

20

Small-scale

0.602

High

377770

GCR
Glucocorticoid receptor

3

20

Small-scale

0.594

High

790056

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

Small-scale

0.589

High

613604

SFPQ
Splicing factor, proline- and glutamine-rich

1

0

Small-scale

0.586

High

964073

SRSF2
Serine/arginine-rich splicing factor 2

1

0

Small-scale

0.586

High

1075763

SF01
Splicing factor 1

1

0

Small-scale

0.586

High

1350416

MYEF2
Myelin expression factor 2

1

0

Small-scale

0.586

High

225430

MED14
Mediator of RNA polymerase II transcription subunit 14

1

1

Small-scale

0.561

High

500508

THB
Thyroid hormone receptor beta

1

20

Small-scale

0.561

High

1076210

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

Small-scale

0.561

High

1079731

USF2
Upstream stimulatory factor 2

1

2

Small-scale

0.561

High

1085287

NRF1
Nuclear respiratory factor 1

1

1

Small-scale

0.561

High

1147423

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

1

Small-scale

0.561

High

1270814

CBP
CREB-binding protein

1

1

Small-scale

0.561

High

1274359

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

Small-scale

0.561

High

1281449

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.561

High

1289463

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.561

High

1300895

NR1H4
Bile acid receptor

1

20

Small-scale

0.561

High

387655

P53
Cellular tumor antigen p53

1

0

Small-scale

0.537

High

1078546

NCOA1
Nuclear receptor coactivator 1

1

0

Small-scale

0.537

High

1304952

NECD
Necdin

1

0

Small-scale

0.537

High

1346442

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

Small-scale

0.537

High

781475

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.513

High

607842

USF1
Upstream stimulatory factor 1

1

2

Small-scale

0.501

High

846429

RORG
Nuclear receptor ROR-gamma

1

16

Small-scale

0.501

High

1087452

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.493

High

1269828

ESR2
Estrogen receptor beta

1

20

High-throughput

0.481

High

929090

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.480

High

930428

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

1057799

NCOA6
Nuclear receptor coactivator 6

1

0

Small-scale

0.480

High

278177

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

Small-scale

0.479

High

587736

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

Small-scale

0.479

High

599741

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

Small-scale

0.479

High

795608

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

20

Small-scale

0.479

High

848311

HCFC1
Host cell factor 1

1

1

Small-scale

0.479

High

978921

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

999164

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.479

High

1054302

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

1

Small-scale

0.479

High

1061334

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

20

Small-scale

0.479

High

1271461

KAT2A
Histone acetyltransferase KAT2A

1

1

Small-scale

0.479

High

1281623

RNF34
E3 ubiquitin-protein ligase RNF34

1

1

Small-scale

0.479

High

385891

CPNS1
Calpain small subunit 1

1

0

High-throughput

0.460

High

235308

OGA
Protein O-GlcNAcase

1

0

Small-scale

0.458

High

339077

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

669038

PML
Protein PML

1

0

Small-scale

0.458

High

809466

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.458

High

819679

NRIP1
Nuclear receptor-interacting protein 1

1

0

Small-scale

0.458

High

1037109

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

Small-scale

0.458

High

1304159

RING2
E3 ubiquitin-protein ligase RING2

1

0

Small-scale

0.458

High

1334009

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

Small-scale

0.458

High

1354051

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.458

High


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Last updated: 15 Jul 2024