Protein: TRIM8
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)

Gene: TRIM8
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q9BZR9

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007249 - canonical NF-kappaB signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

168565

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

3

20

High-throughput

0.861

High

906773

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

20

High-throughput

0.861

High

1420192

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.861

High

982310

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.800

High

931592

RD23A
UV excision repair protein RAD23 homolog A

2

20

High-throughput

0.783

High

180918

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.698

High

623521

RO52
E3 ubiquitin-protein ligase TRIM21

1

18

High-throughput

0.698

High

957189

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

High-throughput

0.698

High

1103935

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

1383929

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1397017

TRI47
E3 ubiquitin-protein ligase TRIM47

1

19

High-throughput

0.698

High

1399967

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

14

High-throughput

0.698

High

1420178

TRI15
E3 ubiquitin-protein ligase TRIM15

1

19

High-throughput

0.698

High

1420179

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

19

High-throughput

0.698

High

1420180

TRIM2
Tripartite motif-containing protein 2

1

19

High-throughput

0.698

High

1420186

TRI39
E3 ubiquitin-protein ligase TRIM39

1

19

High-throughput

0.698

High

214024

M3K7
Mitogen-activated protein kinase kinase kinase 7

4

13

Small-scale

0.692

High

1420177

TRIM8
E3 ubiquitin-protein ligase TRIM8

3

18

Small-scale

0.664

High

1387333

OTUB2
Ubiquitin thioesterase OTUB2

3

15

High-throughput

0.654

High

1396239

TNIP3
TNFAIP3-interacting protein 3

3

12

Small-scale

0.653

High

329102

KLHL2
Kelch-like protein 2

2

8

High-throughput

0.611

High

164635

TNPO2
Transportin-2

2

6

High-throughput

0.606

High

320772

UBXN7
UBX domain-containing protein 7

2

6

High-throughput

0.606

High

853522

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

2

20

High-throughput

0.606

High

885407

HXA1
Homeobox protein Hox-A1

2

20

High-throughput

0.606

High

943813

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

15

High-throughput

0.606

High

1165313

LONF1
LON peptidase N-terminal domain and RING finger protein 1

2

18

High-throughput

0.606

High

1218656

OTU1
Ubiquitin thioesterase OTU1

2

3

High-throughput

0.606

High

1224900

TENS2
Tensin-2

2

6

High-throughput

0.606

High

1315652

RN168
E3 ubiquitin-protein ligase RNF168

2

3

High-throughput

0.606

High

1325116

MTURN
Maturin

2

3

High-throughput

0.606

High

1348488

LNX1
E3 ubiquitin-protein ligase LNX

2

13

High-throughput

0.606

High

1391953

DCNL1
DCN1-like protein 1

2

2

High-throughput

0.606

High

572192

TRI27
Zinc finger protein RFP

1

19

Small-scale

0.590

High

1371665

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

17

High-throughput

0.584

High

1339425

NUD10
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

2

0

High-throughput

0.580

High

396888

ESR1
Estrogen receptor

1

20

Small-scale

0.578

High

468770

HS90B
Heat shock protein HSP 90-beta

1

20

Small-scale

0.561

High

1307146

TCAM1
TIR domain-containing adapter molecule 1

1

3

Small-scale

0.561

High

1337352

CTSR1
Cation channel sperm-associated protein 1

2

10

High-throughput

0.553

High

1420182

F124B
Protein FAM124B

2

4

High-throughput

0.553

High

136725

TRAF5
TNF receptor-associated factor 5

1

20

High-throughput

0.541

High

194333

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.541

High

651429

CBL
E3 ubiquitin-protein ligase CBL

1

9

High-throughput

0.541

High

873999

NRIP1
Nuclear receptor-interacting protein 1

1

1

High-throughput

0.541

High

1022786

XIAP
E3 ubiquitin-protein ligase XIAP

1

5

High-throughput

0.541

High

1093709

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

5

High-throughput

0.541

High

1125217

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

18

High-throughput

0.541

High

1252775

RN111
E3 ubiquitin-protein ligase Arkadia

1

4

High-throughput

0.541

High

1278925

BRAP
BRCA1-associated protein

1

20

High-throughput

0.541

High

1286264

PCGF5
Polycomb group RING finger protein 5

1

19

High-throughput

0.541

High

1307785

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

12

High-throughput

0.541

High

1357984

RN138
E3 ubiquitin-protein ligase RNF138

1

19

High-throughput

0.541

High

1358005

RN141
RING finger protein 141

1

6

High-throughput

0.541

High

1384945

TRI43
Tripartite motif-containing protein 43

1

19

High-throughput

0.541

High

1420181

RNF41
E3 ubiquitin-protein ligase NRDP1

1

19

High-throughput

0.541

High

1420183

RC3H2
Roquin-2

1

8

High-throughput

0.541

High

1420188

RN181
E3 ubiquitin-protein ligase RNF181

1

6

High-throughput

0.541

High

1420190

RBX2
RING-box protein 2

1

4

High-throughput

0.541

High

570971

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

772414

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

High-throughput

0.536

High

1149547

CDSN
Corneodesmosin

1

2

High-throughput

0.536

High

1270819

RUFY3
Protein RUFY3

1

13

High-throughput

0.536

High

1399844

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.518

High

1420185

MSL2
E3 ubiquitin-protein ligase MSL2

1

0

High-throughput

0.518

High

1420187

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.518

High

1096211

TADBP
TAR DNA-binding protein 43

1

20

High-throughput

0.515

High

288508

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

20

High-throughput

0.481

High

639304

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

12

High-throughput

0.481

High

908718

CCNH
Cyclin-H

1

5

High-throughput

0.481

High

1154167

ITSN1
Intersectin-1

1

5

High-throughput

0.481

High

1199457

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

20

High-throughput

0.481

High

1420189

MAGC2
Melanoma-associated antigen C2

1

20

Small-scale

0.481

High

1420191

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

20

High-throughput

0.481

High

143236

NFIB
Nuclear factor 1 B-type

1

9

High-throughput

0.479

High

193303

SOCS1
Suppressor of cytokine signaling 1

1

16

Small-scale

0.479

High

341670

EYA4
Protein phosphatase EYA4

1

8

High-throughput

0.479

High

404395

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

414564

P53
Cellular tumor antigen p53

1

13

Small-scale

0.479

High

451637

GPX1
Glutathione peroxidase 1

1

3

Small-scale

0.479

High

540943

ERG
Transcriptional regulator ERG

1

6

Small-scale

0.479

High

683511

IKBA
NF-kappa-B inhibitor alpha

1

13

Small-scale

0.479

High

848171

MAGA1
Melanoma-associated antigen 1

1

20

Small-scale

0.479

High

913580

KIF11
Kinesin-like protein KIF11

1

20

Small-scale

0.479

High

1033205

EWS
RNA-binding protein EWS

1

14

Small-scale

0.479

High

1087993

NFIA
Nuclear factor 1 A-type

1

9

High-throughput

0.479

High

1093307

FLII
Protein flightless-1 homolog

1

4

Small-scale

0.479

High

1114223

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1133644

NFIX
Nuclear factor 1 X-type

1

10

High-throughput

0.479

High

1415810

KIFC1
Kinesin-like protein KIFC1

1

20

Small-scale

0.479

High

1420194

PIAS3
E3 SUMO-protein ligase PIAS3

1

14

Small-scale

0.479

High

1056951

FMR1
Fragile X messenger ribonucleoprotein 1

1

12

High-throughput

0.457

High

1420184

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

18

Small-scale

0.457

High

1420193

CD2AP
CD2-associated protein

1

10

High-throughput

0.457

High

94329

D6R9G5
Kelch like family member 2

1

15

High-throughput

0.407

High


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Last updated: 11Aug2025