HitPredict

Interactor 1: MEIS1 (O00470)
Homeobox protein Meis1
Gene: MEIS1

Interactor 2: EMX2 (Q04743)
Homeobox protein EMX2 (Empty spiracles homolog 2) (Empty spiracles-like protein 2)
Gene: EMX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0007420 - brain development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 252
+	Hs
		129960 MEIS1_HUMAN (1-390): 7.65e-139: 402: 100.00		TLX2_HUMAN (46-233): 1.01e-34: 127: 26.94
+	Mm
		678762 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		HXA2_MOUSE (40-228): 1.44e-31: 121: 24.50
+	Hs
		129959 MEIS1_HUMAN (1-390): 7.65e-139: 402: 100.00		TLX3_HUMAN (4-248): 8.43e-32: 120: 26.19
+	Hs
		129968 MEIS1_HUMAN (1-390): 7.65e-139: 402: 100.00		TLX1_HUMAN (81-248): 3.5e-30: 116: 28.57
+	Mm
		1141920 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		Q9QX99_MOUSE (81-248): 8.23e-30: 115: 28.57
+	Mm
		453088 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		HXB8_MOUSE (54-242): 2e-30: 115: 23.62
+	Mm
		857948 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		PDX1_MOUSE (26-242): 5.55e-30: 115: 19.18
+	Mm
		956309 MEIS2_MOUSE (1-385): 7e-117: 350: 80.81		EMX1_MOUSE (1-252): 2.67e-41: 143: 60.30
+	Hs
		67814 MEIS2_HUMAN (1-385): 2.83e-116: 348: 80.81		NOTO_HUMAN (17-245): 3.68e-31: 117: 22.75
+	Hs
		154467 MEIS2_HUMAN (1-385): 2.83e-116: 348: 80.81		TLX1_HUMAN (81-248): 3.5e-30: 116: 28.57
+	Dm
		221160 HTH_DROME (1-389): 3.2e-87: 274: 47.00		UBX_DROME (25-215): 5.73e-31: 120: 19.25
+	Hs
		829802 PKNX1_HUMAN (13-379): 5.44e-82: 259: 35.08		HXA1_HUMAN (19-227): 2.16e-33: 125: 23.18
+	Hs
		174014 PKNX1_HUMAN (13-379): 5.44e-82: 259: 35.08		SHOX_HUMAN (138-216): 1.22e-31: 119: 35.44
+	Mm
		447608 PKNX2_MOUSE (1-376): 1.74e-80: 256: 35.47		HXA6_MOUSE (13-230): 7.09e-33: 121: 19.30
+	Mm
		453090 PKNX2_MOUSE (1-376): 1.74e-80: 256: 35.47		HXB8_MOUSE (54-242): 2e-30: 115: 23.62
+	Mm
		192603 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXA6_MOUSE (13-230): 7.09e-33: 121: 19.30
+	Hs
		567798 PBX3_HUMAN (6-390): 8.78e-52: 180: 15.71		HXB8_HUMAN (8-242): 1.19e-31: 118: 21.63
+	Mm
		192610 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXC5_MOUSE (20-221): 1.1e-31: 117: 22.77
+	Mm
		192606 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXD4_MOUSE (24-251): 7.04e-31: 116: 22.37
+	Mm
		192605 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXB8_MOUSE (54-242): 2e-30: 115: 23.62