HitPredict

Interactor 1: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Interactor 2: PHB2 (Q99623)
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
Gene: PHB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	24457600, 18629613
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043433 - negative regulation of DNA-binding transcription factor activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 336 Hs			1 299
+	Hs
		719076 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		718134 BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		1305243 TRIM5_HUMAN (38-285): 1.54e-36: 139: 14.23		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		749811 BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		717490 BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		584886 RO52_HUMAN (36-286): 4.69e-43: 156: 13.55		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		718804 TRI26_HUMAN (36-282): 9.9e-36: 137: 17.90		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		646178 TRI26_HUMAN (36-282): 9.9e-36: 137: 17.90		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93