HitPredict

Interactor 1: LITAF (Q99732)
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
Gene: LITAF

Interactor 2: HECW2 (Q9P2P5)
E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)
Gene: HECW2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 161 Hs			1 1572
+	Hs
		125672 LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		1299608 LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00		NED4L_HUMAN (664-1033): 5.09e-15: 82.9: 15.47
+	Hs
		1306061 LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		808241 LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00		NEDD4_HUMAN (262-640): 1.79e-13: 77.9: 10.41
+	Mm
		808379 LITAF_MOUSE (1-161): 7.43e-50: 159: 85.71		NEDD4_MOUSE (621-851): 2.16e-11: 71: 13.42
+	Hs
		1294843 LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00		ITCH_HUMAN (468-850): 1.52e-10: 68.3: 12.37
+	Hs
		808268 CDIP1_HUMAN (72-161): 2.31e-23: 93: 36.67		NEDD4_HUMAN (262-640): 1.79e-13: 77.9: 10.41
+	Ce
		1276020 Q94184_CAEEL (67-161): 9.08e-21: 84.9: 33.68		WWP1_CAEEL (761-953): 2e-10: 67.9: 18.59