HitPredict

Interactor 1: SNAG (Q99747)
Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma)
Gene: NAPG

Interactor 2: VAMP8 (Q9BV40)
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Gene: VAMP8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~Synaptobrevin
Common GO terms	GO:0005765 - lysosomal membrane GO:0019905 - syntaxin binding GO:0031201 - SNARE complex GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 312 Hs			1 100
+	Hs
		850592 SNAG_HUMAN (1-312): 3.66e-87: 265: 100.00		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		261710 SNAG_HUMAN (1-312): 3.66e-87: 265: 100.00		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		1079416 SNAG_HUMAN (1-312): 3.66e-87: 265: 100.00		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		926249 SNAG_HUMAN (1-312): 3.66e-87: 265: 100.00		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Dm
		1178116 Q9U6R9_DROME (1-312): 3.86e-71: 224: 38.14		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00
+	Zm
		31296 A0A1D6PZ82_MAIZE (6-262): 1.94e-62: 203: 22.22		A0A1D6KH00_MAIZE (6-98): 2.6e-36: 131: 24.73
+	Dm
		577238 Q9U6R9_DROME (1-312): 3.86e-71: 224: 38.14		SYB_DROME (5-95): 3.25e-30: 106: 27.47
+	Dm
		1095560 SNAP_DROME (6-279): 1.99e-65: 209: 17.96		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00
+	Dm
		577215 SNAP_DROME (6-279): 1.99e-65: 209: 17.96		SYB_DROME (5-95): 3.25e-30: 106: 27.47
+	Hs
		850546 SNAA_HUMAN (22-275): 5.22e-67: 213: 20.93		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		261720 SNAB_HUMAN (3-281): 7.17e-68: 215: 21.11		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		261646 SNAA_HUMAN (22-275): 5.22e-67: 213: 20.93		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Dm
		1178122 Q9VH25_DROME (1-290): 3.1e-59: 193: 29.66		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00
+	Mm
		659546 SNAB_MOUSE (3-281): 7.17e-68: 215: 21.11		VAMP2_MOUSE (6-82): 2.47e-23: 88: 35.07
+	Hs
		873545 SNAA_HUMAN (22-275): 5.22e-67: 213: 20.93		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		873576 SNAA_HUMAN (22-275): 5.22e-67: 213: 20.93		VAMP8_HUMAN (1-100): 2.94e-24: 89.6: 100.00
+	Hs
		873528 SNAA_HUMAN (22-275): 5.22e-67: 213: 20.93		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Sc
		696608 SEC17_YEAST (6-276): 1.43e-56: 186: 20.14		NYV1_YEAST (3-99): 2.82e-22: 88.4: 24.75
+	Sc
		678143 SEC17_YEAST (6-276): 1.43e-56: 186: 20.14		SNC1_YEAST (2-79): 5.22e-23: 86.9: 26.92