HitPredict

Interactor 1: SH3G1 (Q99961)
Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)
Gene: SH3GL1

Interactor 2: SH24A (Q9H788)
SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)
Gene: SH2D4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	25416956, 16189514, 32296183, 19060904, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 368 Hs			1 454
+	Hs
		1151016 Q6FGM0_HUMAN (1-368): 7.32e-90: 276: 100.00		SH24A_HUMAN (1-454): 1.2e-138: 407: 100.00
+	Hs
		1052318 SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16		SH24A_HUMAN (1-454): 1.2e-138: 407: 100.00
+	Hs
		207835 PPIP1_HUMAN (13-363): 1.87e-36: 138: 15.87		SH24A_HUMAN (1-454): 1.2e-138: 407: 100.00
+	Mm
		140062 SH3G1_MOUSE (1-368): 7.42e-89: 273: 94.02		P85B_MOUSE (159-451): 1.66e-19: 93.4: 12.62
+	Mm
		643097 SH3G1_MOUSE (1-368): 7.42e-89: 273: 94.02		P85A_MOUSE (342-451): 3.85e-18: 89.2: 23.48
+	Hs
		433485 SHLB2_HUMAN (10-363): 1.2e-58: 196: 22.39		YES_HUMAN (201-454): 1.68e-41: 156: 15.44
+	Hs
		986382 RHG17_HUMAN (6-267): 6.29e-35: 137: 21.83		BTK_HUMAN (137-445): 1.56e-51: 186: 12.16
+	Hs
		561388 SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16		FER_HUMAN (147-445): 1.31e-41: 159: 16.99
+	Hs
		522981 SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16		SRC_HUMAN (238-454): 4.15e-42: 158: 14.56
+	Hs
		433350 SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16		YES_HUMAN (201-454): 1.68e-41: 156: 15.44
+	Hs
		523026 RHG17_HUMAN (6-267): 6.29e-35: 137: 21.83		SRC_HUMAN (238-454): 4.15e-42: 158: 14.56
+	Hs
		924570 SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16		GRB2_HUMAN (310-454): 1.67e-42: 151: 24.83
+	Hs
		411763 RHG17_HUMAN (6-267): 6.29e-35: 137: 21.83		LCK_HUMAN (220-446): 1.05e-41: 156: 17.01
+	Hs
		411715 SPTN1_HUMAN (4-365): 1.47e-33: 134: 15.82		LCK_HUMAN (220-446): 1.05e-41: 156: 17.01
+	Hs
		924636 RHG17_HUMAN (6-267): 6.29e-35: 137: 21.83		GRB2_HUMAN (310-454): 1.67e-42: 151: 24.83
+	Hs
		924555 SPTN1_HUMAN (4-365): 1.47e-33: 134: 15.82		GRB2_HUMAN (310-454): 1.67e-42: 151: 24.83
+	Hs
		562646 SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16		PLCG2_HUMAN (98-454): 9.6e-30: 125: 15.11
+	Hs
		655395 RHG17_HUMAN (6-267): 6.29e-35: 137: 21.83		P85A_HUMAN (341-451): 2.42e-18: 90: 24.14
+	Hs
		796571 SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16		KSYK_HUMAN (273-440): 2.84e-14: 76.8: 23.08
+	Rn
		71363 SRC8_RAT (86-362): 8.29e-37: 140: 14.75		B2RZ33_RAT (346-428): 2.78e-14: 76.1: 30.95