HitPredict

Interactor 1: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Interactor 2: HRH3 (Q9Y5N1)
Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97)
Gene: HRH3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25517094
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 445
+	Hs
		723002 SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00		HRH1_HUMAN (8-428): 1.08e-82: 264: 21.40
+	Mm
		897202 SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86		DRD2_MOUSE (1-429): 1.19e-82: 263: 19.34
+	Hs
		445810 SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00		ADA2A_HUMAN (4-434): 1.05e-80: 258: 27.11
+	Hs
		723003 SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08		HRH1_HUMAN (8-428): 1.08e-82: 264: 21.40
+	Hs
		1307428 SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57		HRH3_HUMAN (1-445): 1.86e-85: 270: 100.00
+	Hs
		436948 SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00		ACM4_HUMAN (12-430): 3.08e-74: 242: 23.28
+	Hs
		445811 SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08		ADA2A_HUMAN (4-434): 1.05e-80: 258: 27.11
+	Hs
		723748 SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00		DRD3_HUMAN (12-429): 1.52e-73: 238: 23.75
+	Hs
		436885 SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00		ACM2_HUMAN (23-432): 2.76e-72: 236: 23.73
+	Hs
		723001 SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57		HRH1_HUMAN (8-428): 1.08e-82: 264: 21.40
+	Hs
		574792 SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00		ADA2B_HUMAN (43-431): 7.05e-72: 235: 24.94
+	Hs
		445809 SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57		ADA2A_HUMAN (4-434): 1.05e-80: 258: 27.11
+	Hs
		436949 SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08		ACM4_HUMAN (12-430): 3.08e-74: 242: 23.28
+	Hs
		723749 SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08		DRD3_HUMAN (12-429): 1.52e-73: 238: 23.75
+	Hs
		436947 SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57		ACM4_HUMAN (12-430): 3.08e-74: 242: 23.28
+	Hs
		723747 SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57		DRD3_HUMAN (12-429): 1.52e-73: 238: 23.75
+	Hs
		436884 SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57		ACM2_HUMAN (23-432): 2.76e-72: 236: 23.73
+	Hs
		574791 SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57		ADA2B_HUMAN (43-431): 7.05e-72: 235: 24.94
+	Dm
		993225 GRAP_DROME (274-344): 7.28e-20: 88.3: 38.03		MOODY_DROME (22-434): 5.5e-62: 214: 16.47
+	Hs
		429008 GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10		ADRB2_HUMAN (328-439): 7.38e-20: 93.3: 22.32