HitPredict

Interactor 1: WDR83 (Q9BRX9)
WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1)
Gene: WDR83

Interactor 2: PRP19 (Q9UMS4)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: PRPF19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005681 - spliceosomal complex GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 315 Hs			1 504
+	Hs
		209498 PLRG1_HUMAN (2-312): 1.61e-88: 275: 23.15		PRP19_HUMAN (1-504): 2.85e-165: 479: 100.00
+	Hs
		236266 PRP17_HUMAN (8-304): 1.94e-87: 274: 23.40		PRP19_HUMAN (1-504): 2.85e-165: 479: 100.00
+	Hs
		1281473 FBXW7_HUMAN (103-315): 7.36e-58: 199: 23.61		PRP19_HUMAN (1-504): 2.85e-165: 479: 100.00
+	Hs
		1288388 SNR40_HUMAN (101-312): 1.44e-55: 185: 18.47		PRP19_HUMAN (1-504): 2.85e-165: 479: 100.00
+	Sp
		144119 YN55_SCHPO (28-288): 7.99e-72: 225: 41.60		PRP19_SCHPO (3-501): 3.8e-95: 298: 27.24
+	Hs
		1288273 WDR83_HUMAN (1-315): 2.96e-102: 303: 100.00		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		209467 PLRG1_HUMAN (2-312): 1.61e-88: 275: 23.15		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		236246 PRP17_HUMAN (8-304): 1.94e-87: 274: 23.40		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		1281292 FBXW7_HUMAN (103-315): 7.36e-58: 199: 23.61		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Hs
		792935 LIS1_HUMAN (63-312): 8.99e-76: 239: 19.78		LIS1_HUMAN (302-504): 3.93e-56: 194: 19.11
+	Mm
		925836 LIS1_MOUSE (63-312): 6.3e-76: 239: 19.78		LIS1_MOUSE (302-504): 2.99e-56: 194: 19.11
+	Hs
		209416 PLRG1_HUMAN (2-312): 1.61e-88: 275: 23.15		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Dm
		1358845 WDS_DROME (2-266): 8.48e-80: 248: 22.99		WDS_DROME (93-337): 9.07e-43: 157: 15.23
+	Dm
		1180742 Q9VYQ9_DROME (2-313): 9.5e-88: 272: 21.78		Q7KLW9_DROME (26-336): 2.38e-31: 128: 13.52
+	Hs
		792949 LIS1_HUMAN (63-312): 8.99e-76: 239: 19.78		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Dm
		1358859 FBXW7_DROME (2-258): 1.53e-61: 213: 21.81		WDS_DROME (93-337): 9.07e-43: 157: 15.23
+	Hs
		197071 SNR40_HUMAN (101-312): 1.44e-55: 185: 18.47		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		903418 FBXW7_HUMAN (103-315): 7.36e-58: 199: 23.61		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		903428 SNR40_HUMAN (101-312): 1.44e-55: 185: 18.47		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		793026 LIS1_HUMAN (63-312): 8.99e-76: 239: 19.78		KTNB1_HUMAN (282-504): 4.25e-12: 70.5: 27.07