Protein: PTPRK
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)

Gene: PTPRK
Organism: Homo sapiens
Interactions: 184
UniProt ID: Q15262

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

411394

INSR
Insulin receptor

4

20

High-throughput

0.899

High

172667

LAMA5
Laminin subunit alpha-5

3

14

High-throughput

0.861

High

338458

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.861

High

413043

CHLE
Cholinesterase

3

4

High-throughput

0.861

High

433152

LAMB1
Laminin subunit beta-1

3

9

High-throughput

0.861

High

612850

FBLN1
Fibulin-1

3

2

High-throughput

0.861

High

1069917

LAMA3
Laminin subunit alpha-3

3

13

High-throughput

0.861

High

1069919

MICA
MHC class I polypeptide-related sequence A

3

5

High-throughput

0.861

High

1069928

SUSD1
Sushi domain-containing protein 1

3

18

High-throughput

0.861

High

1069941

AMGO3
Amphoterin-induced protein 3

3

11

High-throughput

0.861

High

1069952

PXDN
Peroxidasin homolog

3

4

High-throughput

0.861

High

1069955

PCSK5
Proprotein convertase subtilisin/kexin type 5

3

8

High-throughput

0.861

High

1069962

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

3

6

High-throughput

0.861

High

1069983

LRP1B
Low-density lipoprotein receptor-related protein 1B

3

4

High-throughput

0.861

High

1069953

PTPRU
Receptor-type tyrosine-protein phosphatase U

2

18

High-throughput

0.811

High

1069939

ANR46
Ankyrin repeat domain-containing protein 46

2

5

High-throughput

0.789

High

1069929

EST3
Carboxylesterase 3

3

4

High-throughput

0.770

High

877413

LAMB2
Laminin subunit beta-2

2

10

High-throughput

0.705

High

1069940

AMGO1
Amphoterin-induced protein 1

2

8

High-throughput

0.705

High

448945

CD48
CD48 antigen

1

9

High-throughput

0.691

High

685244

CEAM8
Carcinoembryonic antigen-related cell adhesion molecule 8

1

12

High-throughput

0.691

High

713806

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.691

High

1048400

NID2
Nidogen-2

1

3

High-throughput

0.691

High

1069920

HFE
Hereditary hemochromatosis protein

1

6

High-throughput

0.691

High

1069987

BTNL2
Butyrophilin-like protein 2

1

11

High-throughput

0.691

High

1069991

CLC4A
C-type lectin domain family 4 member A

1

7

High-throughput

0.691

High

121159

LEG8
Galectin-8

3

20

High-throughput

0.667

High

167923

NPC1
NPC intracellular cholesterol transporter 1

3

1

High-throughput

0.667

High

206907

CHSTA
Carbohydrate sulfotransferase 10

3

1

High-throughput

0.667

High

253466

PLXA2
Plexin-A2

3

17

High-throughput

0.667

High

276931

ATRN
Attractin

3

8

High-throughput

0.667

High

517944

CO6A1

3

2

High-throughput

0.667

High

518001

CO6A2

3

2

High-throughput

0.667

High

550467

ARSB
Arylsulfatase B

3

4

High-throughput

0.667

High

572363

LEG3
Galectin-3

3

20

High-throughput

0.667

High

782084

WNT5A
Protein Wnt-5a

3

1

High-throughput

0.667

High

864299

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

3

6

High-throughput

0.667

High

869949

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

3

1

High-throughput

0.667

High

1034690

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

3

5

High-throughput

0.667

High

1048327

SCRB2
Lysosome membrane protein 2

3

1

High-throughput

0.667

High

1069924

GT253
Inactive glycosyltransferase 25 family member 3

3

3

High-throughput

0.667

High

1069934

CD109
CD109 antigen

3

1

High-throughput

0.667

High

1069935

UBR3
E3 ubiquitin-protein ligase UBR3

3

1

High-throughput

0.667

High

1069949

SCRB1
Scavenger receptor class B member 1

3

1

High-throughput

0.667

High

1069963

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

3

2

High-throughput

0.667

High

1069966

CNTP3
Contactin-associated protein-like 3

3

6

High-throughput

0.667

High

1069982

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

3

1

High-throughput

0.667

High

574208

BMP7
Bone morphogenetic protein 7

1

0

High-throughput

0.656

High

182161

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

5

High-throughput

0.647

High

383818

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

411728

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.647

High

441507

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.647

High

452426

PGFRB
Platelet-derived growth factor receptor beta

1

18

High-throughput

0.647

High

500966

GHR
Growth hormone receptor

1

17

High-throughput

0.647

High

610409

CBL
E3 ubiquitin-protein ligase CBL

1

6

High-throughput

0.647

High

647584

MK03
Mitogen-activated protein kinase 3

1

11

High-throughput

0.647

High

782790

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.647

High

788993

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.647

High

972328

TIE2
Angiopoietin-1 receptor

1

16

High-throughput

0.647

High

129477

MANBA
Beta-mannosidase

3

0

High-throughput

0.638

High

792191

ECE1
Endothelin-converting enzyme 1

3

0

High-throughput

0.638

High

1019206

HYAL2
Hyaluronidase-2

3

0

High-throughput

0.638

High

1069945

P3H3
Prolyl 3-hydroxylase 3

3

0

High-throughput

0.638

High

1069985

CATF
Cathepsin F

3

0

High-throughput

0.638

High

806534

RL28
Large ribosomal subunit protein eL28

2

1

High-throughput

0.628

High

827392

EFTU
Elongation factor Tu, mitochondrial

2

1

High-throughput

0.628

High

1069992

PCDGG
Protocadherin gamma-B4

2

16

High-throughput

0.628

High

1069995

PCDGD
Protocadherin gamma-B1

2

15

High-throughput

0.628

High

436315

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

564539

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

655375

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

6

High-throughput

0.618

High

660851

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

17

High-throughput

0.618

High

793317

MUC18
Cell surface glycoprotein MUC18

1

16

High-throughput

0.618

High

892385

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

900493

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

915690

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

957400

IDD
Integral membrane protein DGCR2/IDD

1

3

High-throughput

0.618

High

1069932

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

7

High-throughput

0.618

High

1069937

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

10

High-throughput

0.618

High

1069954

ESR2
Estrogen receptor beta

1

1

High-throughput

0.618

High

1069971

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1069974

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

3

High-throughput

0.618

High

1069994

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

2

High-throughput

0.618

High

530668

ITA4
Integrin alpha-4

2

6

High-throughput

0.611

High

119390

LEG9
Galectin-9

3

20

High-throughput

0.609

High

546614

ARSA
Arylsulfatase A

3

4

High-throughput

0.609

High

709251

GALNS
N-acetylgalactosamine-6-sulfatase

3

4

High-throughput

0.609

High

830076

MA2A2
Alpha-mannosidase 2x

3

1

High-throughput

0.609

High

1069926

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

3

1

High-throughput

0.609

High

1069930

ARSK
Arylsulfatase K

3

4

High-throughput

0.609

High

1069960

ARSG
Arylsulfatase G

3

4

High-throughput

0.609

High

1069984

DNJB9
DnaJ homolog subfamily B member 9

3

9

High-throughput

0.609

High

965235

DEF5
Defensin alpha 5

2

0

High-throughput

0.602

High

1069946

LYPD1
Ly6/PLAUR domain-containing protein 1

2

0

High-throughput

0.602

High

883516

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.590

High

230246

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

0

High-throughput

0.586

High

230139

MGRN1
E3 ubiquitin-protein ligase MGRN1

2

0

High-throughput

0.585

High

1069978

MMP26
Matrix metalloproteinase-26

2

2

High-throughput

0.574

High

542330

PLAK
Junction plakoglobin

1

20

Small-scale

0.561

High

717099

CTNB1
Catenin beta-1

1

20

Small-scale

0.561

High

1069943

ERO1B
ERO1-like protein beta

2

1

High-throughput

0.558

High

1069970

Q9H4D1
Protein kinase

1

3

High-throughput

0.555

High

1069936

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.553

High

1069947

MINK1
Misshapen-like kinase 1

1

4

High-throughput

0.553

High

1069967

TANC1
Protein TANC1

1

2

High-throughput

0.553

High

1069914

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

18

Small-scale

0.545

High

121769

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

5

High-throughput

0.541

High

61688

CDHR4
Cadherin-related family member 4

1

19

High-throughput

0.536

High

621369

CMA1
Chymase

1

6

High-throughput

0.536

High

881509

ARL4C
ADP-ribosylation factor-like protein 4C

1

4

High-throughput

0.536

High

984265

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

9

High-throughput

0.536

High

1060436

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

10

High-throughput

0.536

High

1069938

TM11B
Transmembrane protease serine 11B

1

7

High-throughput

0.536

High

1069944

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.536

High

1069965

TMPSD
Transmembrane protease serine 13

1

8

High-throughput

0.536

High

1069980

S39A9
Zinc transporter ZIP9

1

2

High-throughput

0.536

High

1069990

FBX2
F-box only protein 2

1

8

High-throughput

0.536

High

561584

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

High-throughput

0.515

High

328264

BY55
CD160 antigen

1

0

High-throughput

0.513

High

798480

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.513

High

1069981

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.513

High

580235

CADH2
Cadherin-2

1

20

High-throughput

0.501

High

803919

NSF
Vesicle-fusing ATPase

1

9

High-throughput

0.501

High

823400

PAXI
Paxillin

1

10

High-throughput

0.501

High

319561

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.489

High

449266

LEG1
Galectin-1

1

20

High-throughput

0.489

High

885688

NXPH1
Neurexophilin-1

1

1

High-throughput

0.489

High

1069950

OIT3
Oncoprotein-induced transcript 3 protein

1

3

High-throughput

0.489

High

1069951

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

1

High-throughput

0.489

High

1069957

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

3

High-throughput

0.489

High

1069959

LEG12
Galectin-12

1

20

High-throughput

0.489

High

1069969

CSTL1
Cystatin-like 1

1

2

High-throughput

0.489

High

1069972

CST9L
Cystatin-9-like

1

2

High-throughput

0.489

High

1069979

CBLN4
Cerebellin-4

1

3

High-throughput

0.489

High

1069993

KLK5
Kallikrein-5

1

8

High-throughput

0.489

High

931645

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

123603

PGRC1
Membrane-associated progesterone receptor component 1

1

3

Small-scale

0.479

High

165200

PLXB2
Plexin-B2

1

17

High-throughput

0.479

High

205418

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

341551

TPA
Tissue-type plasminogen activator

1

8

High-throughput

0.479

High

850472

PLXA3
Plexin-A3

1

17

High-throughput

0.479

High

890164

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

970920

SP3
Transcription factor Sp3

1

2

High-throughput

0.479

High

1069916

MA2A1
Alpha-mannosidase 2

1

1

High-throughput

0.479

High

1069918

T132A
Transmembrane protein 132A

1

1

High-throughput

0.479

High

1069931

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1069942

FRAS1
Extracellular matrix organizing protein FRAS1

1

6

High-throughput

0.479

High

1069964

PKP4
Plakophilin-4

1

20

High-throughput

0.479

High

1069977

CHSTC
Carbohydrate sulfotransferase 12

1

1

High-throughput

0.479

High

1069986

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1069988

PLXA1
Plexin-A1

1

16

High-throughput

0.479

High

309849

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.464

High

267238

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

High-throughput

0.458

High

1052982

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

Small-scale

0.458

High

1069956

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.458

High

622948

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.439

High

64707

RHG32
Rho GTPase-activating protein 32

1

1

High-throughput

0.437

High

301824

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

High-throughput

0.437

High

315701

SC24B
Protein transport protein Sec24B

1

1

High-throughput

0.437

High

814954

LEG7
Galectin-7

1

20

High-throughput

0.437

High

940931

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

1069989

GNPTG
N-acetylglucosamine-1-phosphotransferase subunit gamma

1

5

High-throughput

0.437

High

1069921

FUT11
Alpha-(1,3)-fucosyltransferase 11

3

0

High-throughput

0.347

High

1069922

MKS3
Meckelin

3

0

High-throughput

0.347

High

1069923

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

3

0

High-throughput

0.347

High

1069948

PGLT1
Protein O-glucosyltransferase 1

3

0

High-throughput

0.347

High

1069958

C102A
Coiled-coil domain-containing protein 102A

3

0

High-throughput

0.347

High

1069961

TECT2
Tectonic-2

3

0

High-throughput

0.347

High

563782

ZNF3
Zinc finger protein 3

2

0

High-throughput

0.328

High

378698

KITH
Thymidine kinase, cytosolic

2

0

High-throughput

0.323

High

794449

BTD
Biotinidase

2

0

High-throughput

0.318

High

657676

LYOX
Protein-lysine 6-oxidase

1

0

Small-scale

0.305

High

263922

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

824925

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.279

Low

1069915

ZNF74
Zinc finger protein 74

1

0

High-throughput

0.279

Low

441064

CO4A2

1

0

High-throughput

0.249

Low

1069927

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.249

Low

1069933

B3GLT
Beta-1,3-glucosyltransferase

1

0

High-throughput

0.249

Low

1069968

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1069973

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1069975

SIAE
Sialate O-acetylesterase

1

0

High-throughput

0.249

Low

1069976

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

1069925

Q6FII1
Glutathione S-transferase kappa

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024