HitPredict

Interactor 1: WDR83 (Q9BRX9)
WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1)
Gene: WDR83

Interactor 2: FYV1 (Q9Y2I7)
1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1)
Gene: PIKFYVE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DEP~WD40
Common GO terms	GO:0010008 - endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 315 Hs			1 2098
+	Hs
		92411 WDR83_HUMAN (1-315): 2.96e-102: 303: 100.00		E9PDH4_HUMAN (1-1440): 0: 1386: 94.65
+	Hs
		821390 WDR83_HUMAN (1-315): 2.96e-102: 303: 100.00		TCPE_HUMAN (449-995): 6.65e-167: 524: 14.80
+	Hs
		573451 WDR83_HUMAN (1-315): 2.96e-102: 303: 100.00		TCPA_HUMAN (470-1004): 9.34e-162: 511: 12.77
+	Hs
		826854 WDR83_HUMAN (1-315): 2.96e-102: 303: 100.00		TCPG_HUMAN (459-1010): 6.42e-159: 502: 17.35
+	Hs
		843361 WDR83_HUMAN (1-315): 2.96e-102: 303: 100.00		TCPD_HUMAN (449-990): 1.17e-145: 465: 16.19
+	Hs
		792942 LIS1_HUMAN (63-312): 8.99e-76: 239: 19.78		TCPG_HUMAN (459-1010): 6.42e-159: 502: 17.35
+	Sp
		251319 YN55_SCHPO (28-288): 7.99e-72: 225: 41.60		TCPG_SCHPO (470-993): 1.18e-154: 490: 20.45
+	Sp
		1319494 YN55_SCHPO (28-288): 7.99e-72: 225: 41.60		TCPE_SCHPO (451-994): 9.72e-153: 485: 14.16
+	Hs
		573406 FBXW7_HUMAN (103-315): 7.36e-58: 199: 23.61		TCPA_HUMAN (470-1004): 9.34e-162: 511: 12.77
+	Hs
		821355 SNR40_HUMAN (101-312): 1.44e-55: 185: 18.47		TCPE_HUMAN (449-995): 6.65e-167: 524: 14.80
+	Hs
		821326 POC1B_HUMAN (2-181): 1.28e-52: 181: 21.43		TCPE_HUMAN (449-995): 6.65e-167: 524: 14.80
+	Hs
		821152 WDR5_HUMAN (140-312): 2.71e-53: 178: 23.60		TCPE_HUMAN (449-995): 6.65e-167: 524: 14.80
+	Hs
		826807 FBXW7_HUMAN (103-315): 7.36e-58: 199: 23.61		TCPG_HUMAN (459-1010): 6.42e-159: 502: 17.35
+	Hs
		573412 SNR40_HUMAN (101-312): 1.44e-55: 185: 18.47		TCPA_HUMAN (470-1004): 9.34e-162: 511: 12.77
+	Hs
		573384 POC1B_HUMAN (2-181): 1.28e-52: 181: 21.43		TCPA_HUMAN (470-1004): 9.34e-162: 511: 12.77
+	Sp
		953440 YN55_SCHPO (28-288): 7.99e-72: 225: 41.60		TCPH_SCHPO (473-1000): 2.93e-145: 465: 17.95
+	Hs
		573201 WDR5_HUMAN (140-312): 2.71e-53: 178: 23.60		TCPA_HUMAN (470-1004): 9.34e-162: 511: 12.77
+	Hs
		826784 POC1B_HUMAN (2-181): 1.28e-52: 181: 21.43		TCPG_HUMAN (459-1010): 6.42e-159: 502: 17.35
+	Hs
		843299 POC1B_HUMAN (2-181): 1.28e-52: 181: 21.43		TCPD_HUMAN (449-990): 1.17e-145: 465: 16.19
+	Sp
		843531 YN55_SCHPO (28-288): 7.99e-72: 225: 41.60		TCPD_SCHPO (471-958): 1.67e-109: 362: 15.60