Protein: LRC8A
Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1)

Gene: LRC8A, LRRC8A
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q8IWT6

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0002329 - pre-B cell differentiation
GO:0005225 - volume-sensitive anion channel activity
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1243374

LRC8B
Volume-regulated anion channel subunit LRRC8B

5

13

Small-scale

0.919

High

1310823

LRC8A
Volume-regulated anion channel subunit LRRC8A

3

18

Small-scale

0.796

High

1310828

LRC8C
Volume-regulated anion channel subunit LRRC8C

2

18

Small-scale

0.754

High

575675

GPIX
Platelet glycoprotein IX

1

11

High-throughput

0.691

High

127369

LEG8
Galectin-8

3

6

High-throughput

0.667

High

1310829

5HT3C
5-hydroxytryptamine receptor 3C

3

7

High-throughput

0.667

High

1237943

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

18

Small-scale

0.665

High

1242848

S39A4
Zinc transporter ZIP4

3

1

High-throughput

0.650

High

1310850

FADS3
Fatty acid desaturase 3

3

0

High-throughput

0.634

High

476503

STS
Steryl-sulfatase

2

1

High-throughput

0.628

High

702803

5HT2C
5-hydroxytryptamine receptor 2C

2

5

High-throughput

0.628

High

1250229

DLK2
Protein delta homolog 2

2

4

High-throughput

0.628

High

355006

CHK2
Serine/threonine-protein kinase Chk2

1

3

Small-scale

0.625

High

126686

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

375699

RASK
GTPase KRas

1

16

High-throughput

0.618

High

401112

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

412221

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

466347

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

581157

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601364

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

953551

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955358

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

962246

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

978143

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

988509

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015583

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1151770

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1271344

LRC8D
Volume-regulated anion channel subunit LRRC8D

1

20

Small-scale

0.618

High

1286823

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.618

High

1310840

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1310842

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

438090

GLPB
Glycophorin-B

2

0

High-throughput

0.602

High

539720

ACHB
Acetylcholine receptor subunit beta

2

4

High-throughput

0.601

High

851165

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

2

2

High-throughput

0.601

High

1310830

CLC4D
C-type lectin domain family 4 member D

1

0

High-throughput

0.586

High

230985

TYOBP
TYRO protein tyrosine kinase-binding protein

2

0

High-throughput

0.576

High

170858

CLGN
Calmegin

2

4

High-throughput

0.549

High

132622

UPK1A
Uroplakin-1a

1

4

High-throughput

0.536

High

248486

O10H2
Olfactory receptor 10H2

1

5

High-throughput

0.536

High

349473

TSN15
Tetraspanin-15

1

3

High-throughput

0.536

High

698857

CALX
Calnexin

1

4

High-throughput

0.536

High

855350

5HT3A
5-hydroxytryptamine receptor 3A

1

9

High-throughput

0.536

High

870745

CXA8
Gap junction alpha-8 protein

1

6

High-throughput

0.536

High

938585

PSA
Puromycin-sensitive aminopeptidase

1

4

High-throughput

0.536

High

1159076

C3AR
C3a anaphylatoxin chemotactic receptor

1

8

High-throughput

0.536

High

1187202

CC50B
Cell cycle control protein 50B

1

1

High-throughput

0.536

High

1195443

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

2

High-throughput

0.536

High

1310825

SIDT2
SID1 transmembrane family member 2

1

3

High-throughput

0.536

High

1310836

CREL1
Protein disulfide isomerase CRELD1

1

2

High-throughput

0.536

High

1310839

TTYH1
Protein tweety homolog 1

1

5

High-throughput

0.536

High

1310847

C5AR2
C5a anaphylatoxin chemotactic receptor 2

1

11

High-throughput

0.536

High

1310848

HCST
Hematopoietic cell signal transducer

1

3

High-throughput

0.536

High

460264

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

High-throughput

0.513

High

1259191

SMIM5
Small integral membrane protein 5

1

0

High-throughput

0.513

High

1277981

KCNKI
Potassium channel subfamily K member 18

1

0

High-throughput

0.513

High

1308497

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

0

High-throughput

0.513

High

1310832

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

1185357

LEG9B
Galectin-9B

1

6

High-throughput

0.489

High

1310835

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.489

High

1310845

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.489

High

125525

LEG9
Galectin-9

1

6

High-throughput

0.479

High

173985

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

6

High-throughput

0.479

High

218430

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

461681

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.479

High

468573

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

540550

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

573564

ENPL
Endoplasmin

1

4

High-throughput

0.479

High

733503

GP183
G-protein coupled receptor 183

1

7

High-throughput

0.479

High

1192255

ZACN
Ligand-gated cation channel ZACN

1

9

High-throughput

0.479

High

1254538

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

1310826

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

1310831

LPAR1
Lysophosphatidic acid receptor 1

1

5

High-throughput

0.479

High

1310843

POPD2
Popeye domain-containing protein 2

1

1

High-throughput

0.479

High

1310846

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.479

High

1310849

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

443870

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

High-throughput

0.458

High

1163371

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

248906

GSDME
Gasdermin-E

1

1

High-throughput

0.445

High

609738

LEG3
Galectin-3

1

6

High-throughput

0.445

High

669343

ACKR3
Atypical chemokine receptor 3

1

9

High-throughput

0.445

High

704037

5HT1E
5-hydroxytryptamine receptor 1E

1

5

High-throughput

0.445

High

886097

CXCR3
C-X-C chemokine receptor type 3

1

6

High-throughput

0.445

High

956931

CXCR4
C-X-C chemokine receptor type 4

1

6

High-throughput

0.445

High

1093538

TRDN
Triadin

1

1

High-throughput

0.445

High

1310824

AGRG5
Adhesion G-protein coupled receptor G5

1

3

High-throughput

0.445

High

1310827

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.445

High

1310837

TM169
Transmembrane protein 169

1

1

High-throughput

0.445

High

1310838

S1PR3
Sphingosine 1-phosphate receptor 3

1

5

High-throughput

0.445

High

106234

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

1310844

ANLN
Anillin

1

4

High-throughput

0.437

High

1086036

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.426

High

1214098

DIK1A
Divergent protein kinase domain 1A

2

0

High-throughput

0.313

High

1310834

BSCL2
Seipin

2

0

High-throughput

0.313

High

948141

D131A
Beta-defensin 131A

1

0

High-throughput

0.279

Low

1310841

IPPK
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.279

Low

253862

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.232

Low

1310833

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025