HitPredict

Interactor 1: UBR1 (Q8IWV7)
E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I)
Gene: UBR1

Interactor 2: FAF2 (Q96CS3)
FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
Gene: FAF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	18775313, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1749 Hs			1 445
+	Hs
		320719 UBR1_HUMAN (1-1749): 0: 2525: 100.00		UBXN7_HUMAN (1-441): 1.1e-116: 352: 16.34
+	Hs
		1311130 UBR1_HUMAN (1-1749): 0: 2525: 100.00		FAF1_HUMAN (112-440): 5.65e-83: 269: 24.79
+	Hs
		1311150 UBR2_HUMAN (21-1749): 0: 2327: 47.00		FAF2_HUMAN (1-445): 1.33e-143: 419: 100.00
+	Hs
		320720 UBR2_HUMAN (21-1749): 0: 2327: 47.00		UBXN7_HUMAN (1-441): 1.1e-116: 352: 16.34
+	Hs
		1046384 UBR1_HUMAN (1-1749): 0: 2525: 100.00		UBXN1_HUMAN (295-439): 7.97e-19: 88.4: 16.36
+	Hs
		1311191 UBR2_HUMAN (21-1749): 0: 2327: 47.00		FAF1_HUMAN (112-440): 5.65e-83: 269: 24.79
+	Hs
		1046385 UBR2_HUMAN (21-1749): 0: 2327: 47.00		UBXN1_HUMAN (295-439): 7.97e-19: 88.4: 16.36