Protein: UBR1
E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I)

Gene: UBR1
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q8IWV7

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000502 - proteasome complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

990975

UBE2B
Ubiquitin-conjugating enzyme E2 B

4

14

Small-scale

0.893

High

884359

UBE2A
Ubiquitin-conjugating enzyme E2 A

2

14

Small-scale

0.775

High

376867

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

4

3

High-throughput

0.694

High

982238

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

11

High-throughput

0.647

High

1064353

DEMA
Dematin

3

0

High-throughput

0.638

High

1311132

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

3

0

High-throughput

0.638

High

1234441

MRM1
rRNA methyltransferase 1, mitochondrial

4

1

High-throughput

0.630

High

164382

NRP1
Neuropilin-1

2

1

High-throughput

0.628

High

474805

VIME
Vimentin

2

4

High-throughput

0.628

High

570489

GFAP
Glial fibrillary acidic protein

2

4

High-throughput

0.628

High

876609

NEST
Nestin

2

6

High-throughput

0.628

High

508249

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.618

High

1311110

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

8

Small-scale

0.618

High

181004

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

2

High-throughput

0.609

High

327010

NXPH2
Neurexophilin-2

3

1

High-throughput

0.609

High

569259

YJU2B
Probable splicing factor YJU2B

3

1

High-throughput

0.609

High

611746

BMP7
Bone morphogenetic protein 7

3

3

High-throughput

0.609

High

946249

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

3

2

High-throughput

0.609

High

1279449

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.602

High

1292069

SPA24
Spermatogenesis-associated protein 24

2

0

High-throughput

0.602

High

1311098

PDIP3
Polymerase delta-interacting protein 3

2

0

High-throughput

0.602

High

1311128

RABX5
Rab5 GDP/GTP exchange factor

2

0

High-throughput

0.602

High

1311088

FAF2
FAS-associated factor 2

2

7

High-throughput

0.601

High

1311092

PLIN2
Perilipin-2

1

4

Small-scale

0.578

High

906701

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

11

Small-scale

0.575

High

628587

ISK2
Serine protease inhibitor Kazal-type 2

2

1

High-throughput

0.574

High

664929

CRHBP
Corticotropin-releasing factor-binding protein

2

1

High-throughput

0.574

High

928866

LIPR1
Inactive pancreatic lipase-related protein 1

2

1

High-throughput

0.574

High

1311090

CLCC1
Chloride channel CLIC-like protein 1

2

1

High-throughput

0.574

High

1311101

PDGFD
Platelet-derived growth factor D

2

2

High-throughput

0.574

High

1311104

SIL1
Nucleotide exchange factor SIL1

2

1

High-throughput

0.574

High

1311136

INSL5
Insulin-like peptide INSL5

2

1

High-throughput

0.574

High

370719

FOS
Protein c-Fos

1

3

Small-scale

0.561

High

377830

IGF2
Insulin-like growth factor 2

2

3

High-throughput

0.549

High

1311078

PGLT1
Protein O-glucosyltransferase 1

2

1

High-throughput

0.549

High

1311126

MRM2
rRNA methyltransferase 2, mitochondrial

2

1

High-throughput

0.549

High

1102723

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

1

High-throughput

0.541

High

227244

KRT86
Keratin, type II cuticular Hb6

1

1

High-throughput

0.536

High

320719

UBXN7
UBX domain-containing protein 7

1

7

High-throughput

0.536

High

351394

CBX7
Chromobox protein homolog 7

1

1

High-throughput

0.536

High

762141

CNR2
Cannabinoid receptor 2

1

1

Small-scale

0.536

High

946668

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

1

High-throughput

0.536

High

1046384

UBXN1
UBX domain-containing protein 1

1

5

High-throughput

0.536

High

1127659

KT33B
Keratin, type I cuticular Ha3-II

1

3

High-throughput

0.536

High

1146026

K1H1
Keratin, type I cuticular Ha1

1

3

High-throughput

0.536

High

1216671

CROCC
Rootletin

1

1

High-throughput

0.536

High

1311084

SPSB4
SPRY domain-containing SOCS box protein 4

1

3

High-throughput

0.536

High

1311115

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

1

High-throughput

0.536

High

1311130

FAF1
FAS-associated factor 1

1

7

High-throughput

0.536

High

391634

FRIH
Ferritin heavy chain

1

0

High-throughput

0.518

High

553719

ANXA3
Annexin A3

1

0

High-throughput

0.518

High

783161

ARL3
ADP-ribosylation factor-like protein 3

1

0

High-throughput

0.518

High

886293

ARL4D
ADP-ribosylation factor-like protein 4D

1

0

High-throughput

0.518

High

895494

SPB9
Serpin B9

1

0

High-throughput

0.518

High

955359

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.518

High

1198776

QORX
Quinone oxidoreductase PIG3

1

0

High-throughput

0.518

High

1311097

BTBD2
BTB/POZ domain-containing protein 2

1

0

High-throughput

0.518

High

1279615

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

954713

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.513

High

1036667

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

0

High-throughput

0.513

High

1112908

CUL2
Cullin-2

1

0

High-throughput

0.513

High

1311077

ZN383
Zinc finger protein 383

1

0

High-throughput

0.513

High

1311082

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.513

High

1311085

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.513

High

1311095

FEM1A
Protein fem-1 homolog A

1

0

High-throughput

0.513

High

1311118

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

0

High-throughput

0.513

High

1311137

CBPQ
Carboxypeptidase Q

1

0

High-throughput

0.513

High

221155

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.508

High

891665

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.508

High

1157279

LAMA4
Laminin subunit alpha-4

1

1

High-throughput

0.494

High

1311133

RASD1
Dexamethasone-induced Ras-related protein 1

1

0

High-throughput

0.493

High

377643

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.489

High

409590

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

2

High-throughput

0.489

High

506870

CFC1
Cryptic protein

1

3

High-throughput

0.489

High

561374

TDGF1
Protein Cripto

1

3

High-throughput

0.489

High

641313

SIAL
Integrin-binding sialoprotein

1

1

High-throughput

0.489

High

724979

HXA7
Homeobox protein Hox-A7

1

2

High-throughput

0.489

High

956083

SPCS3
Signal peptidase complex subunit 3

1

1

High-throughput

0.489

High

1161848

AMHR2
Anti-Muellerian hormone type-2 receptor

1

1

High-throughput

0.489

High

1224817

EGFLA
Pikachurin

1

1

High-throughput

0.489

High

1310994

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.489

High

1311080

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

1

High-throughput

0.489

High

1311081

G45IP
Large ribosomal subunit protein mL64

1

1

High-throughput

0.489

High

1311096

CRDL1
Chordin-like protein 1

1

2

High-throughput

0.489

High

1311100

CD244
Natural killer cell receptor 2B4

1

2

High-throughput

0.489

High

1311102

WN10A
Protein Wnt-10a

1

2

High-throughput

0.489

High

1311106

IL25
Interleukin-25

1

1

High-throughput

0.489

High

1311111

CBX8
Chromobox protein homolog 8

1

1

High-throughput

0.489

High

1311125

CLC2D
C-type lectin domain family 2 member D

1

1

High-throughput

0.489

High

352717

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

665269

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.486

High

1060191

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.486

High

404201

GCR
Glucocorticoid receptor

1

1

Small-scale

0.481

High

938169

PKNX1
Homeobox protein PKNOX1

1

1

Small-scale

0.481

High

1311086

NTAN1
Protein N-terminal asparagine amidohydrolase

1

1

Small-scale

0.481

High

1311089

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

1

Small-scale

0.481

High

1311093

CDC6
Cell division control protein 6 homolog

1

0

Small-scale

0.480

High

315759

RECQ4
ATP-dependent DNA helicase Q4

1

1

Small-scale

0.479

High

485249

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

799275

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

1254540

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1311122

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1311127

HERC5
E3 ISG15--protein ligase HERC5

1

1

Small-scale

0.479

High

1311131

NSF1C
NSFL1 cofactor p47

1

1

High-throughput

0.479

High

785845

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

1311099

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

1311113

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1311091

S1PR3
Sphingosine 1-phosphate receptor 3

1

1

High-throughput

0.445

High

617173

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

3

Small-scale

0.439

High

372509

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

1243901

SG11A
Sperm-associated antigen 11A

1

1

High-throughput

0.437

High

1311107

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

2

High-throughput

0.437

High

859895

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.426

High

898499

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.426

High

1311117

CEP72
Centrosomal protein of 72 kDa

1

0

High-throughput

0.426

High

1311121

PISD
Phosphatidylserine decarboxylase proenzyme, mitochondrial

1

0

High-throughput

0.426

High

1311135

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.426

High

890703

RGS4
Regulator of G-protein signaling 4

1

1

Small-scale

0.408

High

1064636

SG11B
Sperm-associated antigen 11B

1

1

High-throughput

0.407

High

1101576

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.407

High

1194789

GRPL2
GLIPR1-like protein 2

1

1

High-throughput

0.407

High

1311129

S39AA
Zinc transporter ZIP10

1

1

High-throughput

0.407

High

1065003

FGL1
Fibrinogen-like protein 1

4

0

High-throughput

0.360

High

1311076

SCML4
Sex comb on midleg-like protein 4

3

0

High-throughput

0.347

High

1311134

ITM2B
Integral membrane protein 2B

3

0

High-throughput

0.347

High

326258

PRS23
Serine protease 23

2

0

High-throughput

0.328

High

1311079

NPB
Neuropeptide B

2

0

High-throughput

0.328

High

1311105

EPN3
Epsin-3

2

0

High-throughput

0.328

High

449496

CRF
Corticoliberin

2

0

High-throughput

0.324

High

1311119

DJB11
DnaJ homolog subfamily B member 11

2

0

High-throughput

0.323

High

1311114

NUA4L
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

1

0

High-throughput

0.282

High

1311116

ARL15
ADP-ribosylation factor-like protein 15

1

0

High-throughput

0.282

High

1311124

TKNK
Tachykinin-3

1

0

High-throughput

0.282

High

532025

PF4V
Platelet factor 4 variant

1

0

High-throughput

0.279

Low

652654

GNLY
Granulysin

1

0

High-throughput

0.279

Low

664529

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.279

Low

846120

CATO
Cathepsin O

1

0

High-throughput

0.279

Low

1210429

LY65C
Lymphocyte antigen 6 complex locus protein G5c

1

0

High-throughput

0.279

Low

1279818

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.279

Low

1292657

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.279

Low

1311083

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.279

Low

1311087

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.279

Low

1311094

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.279

Low

1311103

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.279

Low

1311108

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.279

Low

1311109

GREM2
Gremlin-2

1

0

High-throughput

0.279

Low

389851

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

458918

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

1311123

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.265

Low

412222

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

543430

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

0

High-throughput

0.249

Low

589101

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

1311112

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

211683

LEU1
Leukemia-associated protein 1

1

0

High-throughput

0.238

Low

262177

KERA
Keratocan

1

0

High-throughput

0.232

Low

704038

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.232

Low

1185882

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.232

Low

1279050

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

1311120

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025