Protein: UBR2
E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)

Gene: UBR2
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q8IWV8

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

990976

UBE2B
Ubiquitin-conjugating enzyme E2 B

4

14

Small-scale

0.878

High

884360

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

14

Small-scale

0.724

High

164383

NRP1
Neuropilin-1

4

1

High-throughput

0.691

High

594849

GCFC2
Intron Large complex component GCFC2

4

0

High-throughput

0.661

High

618196

AMD
Peptidyl-glycine alpha-amidating monooxygenase

4

0

High-throughput

0.661

High

970746

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

13

Small-scale

0.647

High

982239

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

11

High-throughput

0.647

High

920670

NUDT6
Nucleoside diphosphate-linked moiety X motif 6

3

0

High-throughput

0.638

High

1234442

MRM1
rRNA methyltransferase 1, mitochondrial

4

1

High-throughput

0.630

High

508250

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.618

High

856788

BAG6
Large proline-rich protein BAG6

1

1

Small-scale

0.618

High

1311168

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

9

Small-scale

0.618

High

1311177

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

8

Small-scale

0.618

High

664930

CRHBP
Corticotropin-releasing factor-binding protein

2

1

High-throughput

0.601

High

799276

BRCA1
Breast cancer type 1 susceptibility protein

2

1

High-throughput

0.584

High

1311185

ZRAN1
Ubiquitin thioesterase ZRANB1

2

2

High-throughput

0.584

High

1157463

PKN1
Serine/threonine-protein kinase N1

2

0

High-throughput

0.580

High

1162824

H2A2C
Histone H2A type 2-C

2

0

Small-scale

0.577

High

931559

RD23A
UV excision repair protein RAD23 homolog A

1

2

High-throughput

0.575

High

569260

YJU2B
Probable splicing factor YJU2B

2

1

High-throughput

0.574

High

628588

ISK2
Serine protease inhibitor Kazal-type 2

2

1

High-throughput

0.574

High

1311196

INSL5
Insulin-like peptide INSL5

2

1

High-throughput

0.574

High

327011

NXPH2
Neurexophilin-2

2

1

High-throughput

0.558

High

377831

IGF2
Insulin-like growth factor 2

2

3

High-throughput

0.549

High

956084

SPCS3
Signal peptidase complex subunit 3

2

1

High-throughput

0.549

High

320720

UBXN7
UBX domain-containing protein 7

1

7

High-throughput

0.536

High

372510

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.536

High

570490

GFAP
Glial fibrillary acidic protein

1

4

High-throughput

0.536

High

724980

HXA7
Homeobox protein Hox-A7

1

2

High-throughput

0.536

High

876610

NEST
Nestin

1

6

High-throughput

0.536

High

946669

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

1

High-throughput

0.536

High

1046385

UBXN1
UBX domain-containing protein 1

1

5

High-throughput

0.536

High

1216672

CROCC
Rootletin

1

1

High-throughput

0.536

High

1250847

CRDL2
Chordin-like protein 2

1

3

High-throughput

0.536

High

1311141

TEX19
Testis-expressed protein 19

1

1

High-throughput

0.536

High

1311150

FAF2
FAS-associated factor 2

1

7

High-throughput

0.536

High

1311182

PAK5
Serine/threonine-protein kinase PAK 5

1

1

High-throughput

0.536

High

1311191

FAF1
FAS-associated factor 1

1

7

High-throughput

0.536

High

1311149

NTAN1
Protein N-terminal asparagine amidohydrolase

1

1

Small-scale

0.527

High

1311153

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

1

Small-scale

0.527

High

1311159

CLCC1
Chloride channel CLIC-like protein 1

2

1

Small-scale

0.521

High

945542

RGS8
Regulator of G-protein signaling 8

1

1

High-throughput

0.515

High

656012

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

1050339

SRY
Sex-determining region Y protein

1

0

High-throughput

0.513

High

1204371

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1311140

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

1311143

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.513

High

1311151

NUD16
U8 snoRNA-decapping enzyme

1

0

High-throughput

0.513

High

1311155

MET2A
tRNA N(3)-cytidine methyltransferase METTL2A

1

0

High-throughput

0.513

High

1311167

PAR6B
Partitioning defective 6 homolog beta

1

0

High-throughput

0.513

High

1311180

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

High-throughput

0.513

High

1311192

FOXJ3
Forkhead box protein J3

1

0

High-throughput

0.513

High

384477

CRYAA
Alpha-crystallin A chain

1

1

High-throughput

0.501

High

71391

HECA2
HEPACAM family member 2

1

1

High-throughput

0.489

High

377644

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.489

High

409591

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

2

High-throughput

0.489

High

506871

CFC1
Cryptic protein

1

3

High-throughput

0.489

High

561375

TDGF1
Protein Cripto

1

3

High-throughput

0.489

High

641314

SIAL
Integrin-binding sialoprotein

1

1

High-throughput

0.489

High

651603

IBP4
Insulin-like growth factor-binding protein 4

1

1

High-throughput

0.489

High

928867

LIPR1
Inactive pancreatic lipase-related protein 1

1

1

High-throughput

0.489

High

1310995

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.489

High

1311144

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

1

High-throughput

0.489

High

1311145

G45IP
Large ribosomal subunit protein mL64

1

1

High-throughput

0.489

High

1311148

PMEPA
Protein TMEPAI

1

2

High-throughput

0.489

High

1311154

RCC1L
RCC1-like G exchanging factor-like protein

1

2

High-throughput

0.489

High

1311169

WN10A
Protein Wnt-10a

1

2

High-throughput

0.489

High

1311170

SIL1
Nucleotide exchange factor SIL1

1

1

High-throughput

0.489

High

1311171

IL25
Interleukin-25

1

1

High-throughput

0.489

High

1311186

CLC2D
C-type lectin domain family 2 member D

1

1

High-throughput

0.489

High

617174

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

3

Small-scale

0.481

High

980907

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

Small-scale

0.480

High

315760

RECQ4
ATP-dependent DNA helicase Q4

1

1

Small-scale

0.479

High

332321

ATE1
Arginyl-tRNA--protein transferase 1

1

1

Small-scale

0.479

High

376868

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

3

High-throughput

0.479

High

485250

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

978144

RHOB
Rho-related GTP-binding protein RhoB

1

1

High-throughput

0.479

High

1135599

UBX2B
UBX domain-containing protein 2B

1

1

High-throughput

0.479

High

1254541

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1311161

PLIN2
Perilipin-2

1

4

Small-scale

0.479

High

1311164

DUS26
Dual specificity protein phosphatase 26

1

1

High-throughput

0.479

High

1311172

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

2

High-throughput

0.479

High

1311189

HERC5
E3 ISG15--protein ligase HERC5

1

1

Small-scale

0.479

High

378507

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

551147

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

651376

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

927052

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

945818

EPIPL
Epiplakin

1

0

Small-scale

0.458

High

971755

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

1311176

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1311188

XPO7
Exportin-7

1

0

High-throughput

0.458

High

420013

B3A2
Anion exchange protein 2

1

1

High-throughput

0.445

High

1311181

SENP1
Sentrin-specific protease 1

1

1

High-throughput

0.445

High

281615

MTX2
Metaxin-2

1

0

High-throughput

0.426

High

923707

SMTN
Smoothelin

1

0

High-throughput

0.426

High

1097705

STK3
Serine/threonine-protein kinase 3

1

0

High-throughput

0.426

High

1311152

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.426

High

1311157

CAR19
Caspase recruitment domain-containing protein 19

1

0

High-throughput

0.426

High

1311163

MIC25
MICOS complex subunit MIC25

1

0

High-throughput

0.426

High

1311174

SAV1
Protein salvador homolog 1

1

0

High-throughput

0.426

High

1311178

SYSM
Serine--tRNA ligase, mitochondrial

1

0

High-throughput

0.426

High

1311195

RBM7
RNA-binding protein 7

1

0

High-throughput

0.426

High

1311197

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

0

High-throughput

0.426

High

377314

VIP
VIP peptides [Cleaved into: Intestinal peptide PHV-42

1

1

High-throughput

0.407

High

1157370

EXT1
Exostosin-1

1

1

High-throughput

0.407

High

1177162

MICB
MHC class I polypeptide-related sequence B

1

1

High-throughput

0.407

High

1194790

GRPL2
GLIPR1-like protein 2

1

1

High-throughput

0.407

High

1245090

RHDF2
Inactive rhomboid protein 2

1

2

High-throughput

0.407

High

1309590

SPA12
Serpin A12

1

1

High-throughput

0.407

High

1311138

MICU2
Calcium uptake protein 2, mitochondrial

1

1

High-throughput

0.407

High

1311142

PGLT1
Protein O-glucosyltransferase 1

1

1

High-throughput

0.407

High

1311147

EXT2
Exostosin-2

1

1

High-throughput

0.407

High

1311162

MICU1
Calcium uptake protein 1, mitochondrial

1

1

High-throughput

0.407

High

1311166

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

1

High-throughput

0.407

High

1311187

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.407

High

1311190

S39AA
Zinc transporter ZIP10

1

1

High-throughput

0.407

High

1249616

PXDC2
Plexin domain-containing protein 2

4

0

High-throughput

0.360

High

211208

CMIP4
Ciliary microtubule inner protein 4

3

0

High-throughput

0.347

High

1311146

PKHO2
Pleckstrin homology domain-containing family O member 2

3

0

High-throughput

0.347

High

405200

SODM
Superoxide dismutase [Mn], mitochondrial

3

0

High-throughput

0.342

High

1085950

HYAL1
Hyaluronidase-1

2

0

High-throughput

0.328

High

1311175

SMOC1
SPARC-related modular calcium-binding protein 1

2

0

High-throughput

0.328

High

1311193

HS3S2
Heparan sulfate glucosamine 3-O-sulfotransferase 2

2

0

High-throughput

0.328

High

1143744

PON2
Serum paraoxonase/arylesterase 2

2

0

High-throughput

0.318

High

1147369

EPHA7
Ephrin type-A receptor 7

2

0

Small-scale

0.318

High

1311183

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

2

0

Small-scale

0.318

High

907162

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

932906

P5CS
Delta-1-pyrroline-5-carboxylate synthase

2

0

Small-scale

0.298

High

377241

SOM2
Growth hormone variant

1

0

High-throughput

0.279

Low

476530

CEL3B
Chymotrypsin-like elastase family member 3B

1

0

High-throughput

0.279

Low

1012212

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.279

Low

1099630

NOGG
Noggin

1

0

High-throughput

0.279

Low

1181066

DB110
Beta-defensin 110

1

0

High-throughput

0.279

Low

1311139

CA087
Uncharacterized protein C1orf87

1

0

High-throughput

0.279

Low

1311184

DKK4
Dickkopf-related protein 4

1

0

High-throughput

0.279

Low

66232

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

Small-scale

0.249

Low

218432

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

283907

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

Small-scale

0.249

Low

1231993

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1311158

SNX18
Sorting nexin-18

1

0

Small-scale

0.249

Low

276152

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.232

Low

1131473

MBTP1
Membrane-bound transcription factor site-1 protease

1

0

High-throughput

0.232

Low

1178971

EX3L2
Exocyst complex component 3-like protein 2

1

0

High-throughput

0.232

Low

1244555

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

1311156

SMIM8
Small integral membrane protein 8

1

0

High-throughput

0.232

Low

1311160

HPLN3
Hyaluronan and proteoglycan link protein 3

1

0

High-throughput

0.232

Low

1311165

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

0

High-throughput

0.232

Low

1311173

RHBG
Ammonium transporter Rh type B

1

0

High-throughput

0.232

Low

1311179

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.232

Low

1311194

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025