HitPredict

Interactor 1: PCGF1 (Q9BSM1)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Interactor 2: CBX8 (Q9HC52)
Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)
Gene: CBX8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

Property	Details
Experiments	26687479, 27705803, 27505670, 33961781, 24981860, 21282530
Identification Methods	biochemical, affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 259 Hs			1 389
+	Hs
		718213 BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29		CBX8_HUMAN (1-389): 5.01e-104: 314: 100.00
+	Mm
		639481 BMI1_MOUSE (30-255): 1.56e-62: 200: 35.59		CBX8_MOUSE (1-389): 2.38e-101: 306: 84.58
+	Hs
		316141 PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00		CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26
+	Hs
		123312 PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		315976 BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29		CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26
+	Hs
		1059189 PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00		CBX2_HUMAN (2-348): 3.75e-46: 167: 22.03
+	Hs
		123193 BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		315977 PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57		CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26
+	Hs
		123194 PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		327860 PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00		CBX7_HUMAN (1-235): 2.71e-41: 147: 28.46
+	Hs
		718131 BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29		MPP8_HUMAN (6-356): 2.27e-52: 188: 18.85
+	Dr
		1186372 BMI1B_DANRE (30-255): 6.8e-65: 207: 36.44		Q804D1_DANRE (1-249): 1.15e-47: 170: 26.91
+	Hs
		717831 BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29		CBX2_HUMAN (2-348): 3.75e-46: 167: 22.03
+	Dr
		1193374 BMI1A_DANRE (30-255): 2.14e-61: 197: 35.59		Q804D1_DANRE (1-249): 1.15e-47: 170: 26.91
+	Mm
		639466 BMI1_MOUSE (30-255): 1.56e-62: 200: 35.59		CBX2_MOUSE (2-335): 3.31e-46: 167: 21.11
+	Hs
		1027226 PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00		CBX3_HUMAN (9-144): 1.3e-26: 106: 25.74
+	Hs
		327830 BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29		CBX7_HUMAN (1-235): 2.71e-41: 147: 28.46
+	Hs
		949871 PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00		CBX1_HUMAN (17-122): 3.63e-23: 97.5: 28.97
+	Hs
		717776 BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29		CBX3_HUMAN (9-144): 1.3e-26: 106: 25.74
+	Hs
		717529 BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29		CBX5_HUMAN (11-144): 1.06e-25: 104: 25.00