HitPredict

Interactor 1: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Interactor 2: EP400 (Q96L91)
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
Gene: EP400

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37071664, 37059091
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1834 Hs			1 3159
+	Hs
		1132819 SLX4_HUMAN (1-1834): 0: 1473: 100.00		CHD4_HUMAN (1499-2520): 2.75e-159: 548: 13.32
+	Hs
		1186489 SLX4_HUMAN (1-1834): 0: 1473: 100.00		CHD9_HUMAN (1564-2538): 1.63e-137: 487: 12.82
+	Hs
		1314428 SLX4_HUMAN (1-1834): 0: 1473: 100.00		CHD8_HUMAN (1505-2480): 7.13e-134: 475: 12.52
+	Hs
		903409 SLX4_HUMAN (1-1834): 0: 1473: 100.00		SMCA4_HUMAN (2530-2882): 2.27e-09: 65.7: 10.62
+	Hs
		854231 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		EP400_HUMAN (1-3159): 0: 1359: 100.00
+	Hs
		854060 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		CHD4_HUMAN (1499-2520): 2.75e-159: 548: 13.32
+	Hs
		1129591 MDC1_HUMAN (757-1462): 4.4e-17: 90.6: 10.56		CHD4_HUMAN (1499-2520): 2.75e-159: 548: 13.32
+	Hs
		854319 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		CHD8_HUMAN (1505-2480): 7.13e-134: 475: 12.52
+	Hs
		853939 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		SMCA2_HUMAN (1506-2307): 1.6e-136: 473: 14.77
+	Hs
		1030699 ANK2_HUMAN (790-1770): 6.65e-09: 63.5: 12.86		CHD8_HUMAN (1505-2480): 7.13e-134: 475: 12.52
+	Hs
		854358 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		CHD7_HUMAN (20-953): 6.2e-16: 87.6: 10.79
+	Hs
		903530 CABIN_HUMAN (864-1723): 7.69e-09: 63.1: 10.42		SMCA4_HUMAN (2530-2882): 2.27e-09: 65.7: 10.62