HitPredict

Interactor 1: HOIL1 (Q9BYM8)
RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3)
Gene: RBCK1

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 0.60 0.760

The method score is based on:

Property Details
Experiments 19675569, 27893701, 21455180, 23986494, 28249776, 30913450, 33815386, 20098747, 23032186, 21709223, 21811235, 23732909
Identification Methods enzymatic study, affinity chromatography technology, pull down, anti tag coimmunoprecipitation, protein array, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0042742 - defense response to bacterium
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0046872 - metal ion binding
GO:0050852 - T cell receptor signaling pathway
and 1 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 510
Hs

1 419
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Last updated: 15 Jul 2024