HitPredict

Interactor 1: IL2RB (P16297)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (p70-75) (CD antigen CD122)
Gene: IL2RB

Interactor 2: SHC1 (P98083)
SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	8294403
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 539 Mm			1 579
+	Hs
		540447 IL2RB_HUMAN (1-539): 0: 561: 56.66		SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17
+	Hs
		666027 IL6RB_HUMAN (20-350): 7.79e-63: 223: 13.75		SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17
+	Hs
		666008 IL2RG_HUMAN (15-354): 9.11e-64: 214: 14.53		SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17
+	Hs
		581152 EPOR_HUMAN (1-375): 5.28e-60: 208: 17.57		SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17
+	Hs
		540464 IL2RB_HUMAN (1-539): 0: 561: 56.66		SHB_HUMAN (385-575): 1.72e-39: 153: 22.66
+	Hs
		540445 IL2RB_HUMAN (1-539): 0: 561: 56.66		P85A_HUMAN (479-575): 6.35e-19: 92.7: 24.75
+	Hs
		540459 IL2RB_HUMAN (1-539): 0: 561: 56.66		GRB2_HUMAN (478-574): 1.33e-15: 77.9: 30.48
+	Hs
		522759 EPOR_HUMAN (1-375): 5.28e-60: 208: 17.57		SRC_HUMAN (334-570): 7.45e-44: 166: 16.87
+	Hs
		145971 EPOR_HUMAN (1-375): 5.28e-60: 208: 17.57		SH2B2_HUMAN (339-577): 5.95e-43: 164: 21.14
+	Hs
		682264 IL2RG_HUMAN (15-354): 9.11e-64: 214: 14.53		SHB_HUMAN (385-575): 1.72e-39: 153: 22.66
+	Hs
		655246 IL6RB_HUMAN (20-350): 7.79e-63: 223: 13.75		P85A_HUMAN (479-575): 6.35e-19: 92.7: 24.75
+	Mm
		719297 IL6RB_MOUSE (24-353): 2.6e-64: 227: 16.47		PTN11_MOUSE (480-576): 1.78e-13: 75.2: 33.33
+	Hs
		770194 IL6RB_HUMAN (20-350): 7.79e-63: 223: 13.75		GRB2_HUMAN (478-574): 1.33e-15: 77.9: 30.48
+	Hs
		581150 EPOR_HUMAN (1-375): 5.28e-60: 208: 17.57		P85A_HUMAN (479-575): 6.35e-19: 92.7: 24.75
+	Hs
		770199 IL6RB_HUMAN (20-350): 7.79e-63: 223: 13.75		PTN11_HUMAN (480-576): 1.78e-13: 75.2: 33.33
+	Hs
		682260 IL2RG_HUMAN (15-354): 9.11e-64: 214: 14.53		GRB2_HUMAN (478-574): 1.33e-15: 77.9: 30.48
+	Hs
		560475 PRLR_HUMAN (24-400): 7.23e-61: 213: 13.57		PTN11_HUMAN (480-576): 1.78e-13: 75.2: 33.33
+	Hs
		581157 EPOR_HUMAN (1-375): 5.28e-60: 208: 17.57		GRB2_HUMAN (478-574): 1.33e-15: 77.9: 30.48
+	Hs
		581161 EPOR_HUMAN (1-375): 5.28e-60: 208: 17.57		PTN11_HUMAN (480-576): 1.78e-13: 75.2: 33.33
+	Hs
		581163 EPOR_HUMAN (1-375): 5.28e-60: 208: 17.57		GRAP_HUMAN (478-572): 1.32e-13: 72.1: 25.25