HitPredict

Interactor 1: ARHG7 (Q9ES28)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (p85SPR)
Gene: Arhgef7

Interactor 2: GIT2 (Q9JLQ2)
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
Gene: GIT2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ArfGap~PH, GIT_SHD~RhoGEF67_u2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 862 Mm			1 708
+	Hs
		1049704 ARHG7_HUMAN (1-772): 0: 606: 91.68		GIT2_HUMAN (1-708): 2.1e-157: 475: 86.03
+	Mm
		1148433 ARHG7_MOUSE (1-862): 0: 648: 100.00		GIT1_MOUSE (1-705): 1.19e-128: 401: 57.94
+	Hs
		1049747 ARHG7_HUMAN (1-772): 0: 606: 91.68		GIT1_HUMAN (1-705): 2.39e-132: 410: 58.80
+	Hs
		1050107 ARHG6_HUMAN (1-861): 7.34e-178: 534: 51.96		GIT2_HUMAN (1-708): 2.1e-157: 475: 86.03
+	Hs
		1066061 ARHG6_HUMAN (1-861): 7.34e-178: 534: 51.96		GIT1_HUMAN (1-705): 2.39e-132: 410: 58.80
+	Mm
		1148429 ARHG6_MOUSE (1-861): 4.26e-173: 521: 51.96		GIT1_MOUSE (1-705): 1.19e-128: 401: 57.94
+	Gg
		1141020 ARHG6_CHICK (1-861): 6.6e-172: 518: 53.92		Q9DG15_CHICK (1-705): 1.06e-126: 395: 58.61
+	Rn
		223056 ARHG7_RAT (158-862): 4.97e-150: 457: 86.81		GIT1_RAT (1-705): 3.22e-127: 397: 57.94
+	Mm
		1206687 ARHG7_MOUSE (1-862): 0: 648: 100.00		ANS1B_MOUSE (204-677): 1.07e-21: 102: 9.94
+	Dm
		1279243 Q9VIN1_DROME (162-853): 1.74e-112: 361: 29.71		GIT_DROME (9-699): 1.18e-98: 321: 35.49
+	Dm
		115754 M9PGB1_DROME (162-823): 1.2e-105: 349: 29.55		GIT_DROME (9-699): 1.18e-98: 321: 35.49
+	Mm
		1141830 ARHG2_MOUSE (96-860): 3.51e-89: 305: 13.17		ASAP1_MOUSE (2-649): 2.94e-61: 224: 15.75
+	Hs
		1273297 ARHG2_HUMAN (96-860): 1.16e-91: 312: 13.17		ASAP1_HUMAN (2-649): 1.96e-56: 210: 13.96
+	Hs
		195795 ITSN1_HUMAN (100-583): 2.53e-78: 280: 17.54		ASAP2_HUMAN (2-568): 3.35e-54: 203: 13.42
+	Hs
		1021479 FARP1_HUMAN (204-604): 1.29e-90: 311: 22.07		ANK3_HUMAN (35-564): 7.63e-42: 166: 13.67
+	Mm
		1112590 ARHGI_MOUSE (214-854): 5.18e-79: 281: 14.27		AGAP2_MOUSE (2-224): 2.82e-51: 194: 30.49
+	Hs
		965179 FARP1_HUMAN (204-604): 1.29e-90: 311: 22.07		ANK2_HUMAN (59-578): 1.24e-22: 106: 12.55
+	Hs
		166988 ARHG2_HUMAN (96-860): 1.16e-91: 312: 13.17		ANR28_HUMAN (261-475): 1.35e-12: 73.2: 8.68
+	Mm
		1206702 ITSN1_MOUSE (107-583): 1.52e-79: 283: 18.18		ANS1B_MOUSE (204-677): 1.07e-21: 102: 9.94
+	Hs
		167038 PKHG1_HUMAN (214-811): 3.41e-85: 299: 19.94		ANR28_HUMAN (261-475): 1.35e-12: 73.2: 8.68