HitPredict

Interactor 1: SHIP1 (Q9ES52)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)
Gene: Inpp5d

Interactor 2: SLAF1 (Q9QUM4)
Signaling lymphocytic activation molecule (SLAM family member 1) (CD antigen CD150)
Gene: Slamf1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.629

Property	Details
Experiments	11477403, 12545173
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032715 - negative regulation of interleukin-6 production
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1191 Mm			1 343
+	Hs
		1030743 SHIP1_HUMAN (4-1187): 0: 868: 87.21		SLAF1_HUMAN (1-343): 4.59e-87: 267: 60.64
+	Hs
		1271567 SHIP1_HUMAN (4-1187): 0: 868: 87.21		SLAF7_HUMAN (5-342): 1.02e-50: 173: 17.89
+	Hs
		1271565 SHIP1_HUMAN (4-1187): 0: 868: 87.21		CD244_HUMAN (32-339): 2.47e-45: 160: 20.25
+	Hs
		1271566 SHIP1_HUMAN (4-1187): 0: 868: 87.21		LY9_HUMAN (19-279): 8.14e-26: 110: 19.32
+	Hs
		176495 SHIP2_HUMAN (4-1109): 0: 676: 39.83		CD244_HUMAN (32-339): 2.47e-45: 160: 20.25
+	Mm
		292400 SH21A_MOUSE (10-104): 1.81e-21: 93.2: 46.32		SLAF1_MOUSE (1-343): 6.54e-96: 289: 100.00
+	Hs
		243137 SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21		SLAF1_HUMAN (1-343): 4.59e-87: 267: 60.64
+	Hs
		155840 SH21B_HUMAN (8-104): 3.51e-20: 89.7: 44.33		SLAF1_HUMAN (1-343): 4.59e-87: 267: 60.64
+	Hs
		243158 SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21		SLAF7_HUMAN (5-342): 1.02e-50: 173: 17.89
+	Hs
		155857 SH21B_HUMAN (8-104): 3.51e-20: 89.7: 44.33		SLAF7_HUMAN (5-342): 1.02e-50: 173: 17.89
+	Hs
		243161 SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21		SLAF5_HUMAN (12-339): 4.23e-47: 164: 20.46
+	Hs
		155858 SH21B_HUMAN (8-104): 3.51e-20: 89.7: 44.33		SLAF5_HUMAN (12-339): 4.23e-47: 164: 20.46
+	Hs
		243155 SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21		CD244_HUMAN (32-339): 2.47e-45: 160: 20.25
+	Hs
		155856 SH21B_HUMAN (8-104): 3.51e-20: 89.7: 44.33		CD244_HUMAN (32-339): 2.47e-45: 160: 20.25
+	Hs
		243153 SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21		SLAF6_HUMAN (13-338): 4.66e-42: 150: 19.88
+	Hs
		155852 SH21B_HUMAN (8-104): 3.51e-20: 89.7: 44.33		SLAF6_HUMAN (13-338): 4.66e-42: 150: 19.88
+	Hs
		211413 SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21		SIGL6_HUMAN (80-217): 5.69e-27: 112: 21.09
+	Hs
		243157 SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21		LY9_HUMAN (19-279): 8.14e-26: 110: 19.32
+	Hs
		177593 SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21		SIGL5_HUMAN (72-213): 1.85e-18: 88.1: 22.37
+	Hs
		243162 SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21		SIGL7_HUMAN (47-342): 2.42e-09: 60.3: 13.94