HitPredict

Interactor 1: FXL15 (Q9H469)
F-box/LRR-repeat protein 15 (F-box only protein 37)
Gene: FBXL15

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	0.60	0.600

Property	Details
Experiments	21572392
Identification Methods	affinity chromatography technology, two hybrid, enzymatic study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 300 Hs			1 757
+	Hs
		1336111 FBXL2_HUMAN (5-249): 1.36e-30: 120: 22.05		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		1330593 FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		1294860 FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		125710 FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		808271 FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		808329 KDM2A_HUMAN (24-284): 2.19e-35: 137: 15.88		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		1299633 FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Hs
		1327912 FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		1176348 FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00		HECW1_HUMAN (2-213): 2.55e-19: 95.6: 15.28
+	Hs
		1330595 FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00		HECW2_HUMAN (1-322): 1.89e-15: 82.9: 14.87