HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PH
Common GO terms	GO:0032266 - phosphatidylinositol-3-phosphate binding GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 779 Hs			1 1116
+	Hs
		1153383 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Hs
		1331666 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		PKHA6_HUMAN (109-1116): 8.74e-73: 264: 28.52
+	Hs
		1331332 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		1331278 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		1153251 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Hs
		1294862 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93
+	Hs
		125712 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51
+	Hs
		1327913 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		WWP1_HUMAN (3-240): 7.83e-24: 110: 14.94
+	Hs
		1022406 TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Hs
		1035417 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25
+	Rn
		1378274 CNKR2_RAT (1-468): 2.97e-47: 183: 14.20		CNKR2_RAT (120-329): 4.34e-47: 185: 26.48
+	Hs
		1153341 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Hs
		596403 RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32		ACAP2_HUMAN (128-692): 2.59e-47: 184: 13.38
+	Hs
		1022438 TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Rn
		1144019 CAPS1_RAT (11-428): 1.59e-46: 181: 10.23		CAPS1_RAT (70-775): 3.49e-41: 167: 11.16
+	Hs
		1167407 MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Hs
		1153259 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Hs
		1167372 MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86