HitPredict

Interactor 1: FNDC5 (Q8NAU1)
Fibronectin type III domain-containing protein 5 (Fibronectin type III repeat-containing protein 2) [Cleaved into: Irisin]
Gene: FNDC5

Interactor 2: CRNN (Q9UBG3)
Cornulin (53 kDa putative calcium-binding protein) (53 kDa squamous epithelial-induced stress protein) (58 kDa heat shock protein) (Squamous epithelial heat shock protein 53) (Tumor-related protein)
Gene: CRNN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 260 Hs			1 495
+	Mm
		1317749 FNDC5_MOUSE (1-260): 3.72e-159: 443: 89.23		TCHL1_MOUSE (1-432): 1.03e-79: 262: 18.95
+	Hs
		706220 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		S10A2_HUMAN (2-96): 3.01e-39: 139: 23.16
+	Hs
		445030 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		S10A9_HUMAN (1-105): 1.12e-36: 133: 25.47
+	Hs
		424226 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		S10A8_HUMAN (1-95): 5.16e-34: 125: 33.68
+	Hs
		1251082 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		RPTN_HUMAN (133-377): 1.84e-16: 84.6: 14.69
+	Mm
		569564 FNDC5_MOUSE (1-260): 3.72e-159: 443: 89.23		S10A6_MOUSE (3-90): 3.24e-30: 114: 25.00
+	Hs
		635616 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		FILA_HUMAN (104-420): 9.53e-13: 73.1: 14.47